SULT1C2 - sulfotransferase family 1C member 2 Gene

Also Known as ST1C1; ST1C2; SULT1C1; humSULTC2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6819

About SULT1C2

Cytogenetic location: 2q12.3 Genomic coordinates (GRCh38): 2:108,288,895-108,309,915 (from NCBI)

This gene has 9 transcripts (splice variants), 152 orthologues and 12 paralogues. Biased expression in stomach (RPKM 61.8), kidney (RPKM 26.2) and 3 other tissues.

Summary

Sulfotransferase Enzymes catalyze the sulfate conjugation of many Hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic Enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that belongs to the SULT1 subfamily, responsible for transferring a sulfo moiety from PAPS to phenol-containing compounds. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

SULT1C2 Products (2)

mRNA Protein Name
NM_001056.4 NP_001047.1 sulfotransferase 1C2 isoform a
NM_176825.3 NP_789795.1 sulfotransferase 1C2 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables aryl sulfotransferase activity IDA
IDA: Inferred from direct assay
10783263 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21044950 GOA
enables sulfotransferase activity IDA
IDA: Inferred from direct assay
19548878 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within sulfation IDA
IDA: Inferred from direct assay
19548878 GOA
involved in sulfation IDA
IDA: Inferred from direct assay
10783263 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SULT1C2 Protein Structure

Sulfotransfer_1

Sulfotransfer_1: Sulfotransferase domain (39 - 288)

  • 0
  • 100
  • 200
  • 296 a.a.
Protein Preferred Names Protein Names

sulfotransferase 1C2

  • SULT1C#1

SULT1C2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SULT1C2 O00338 TINF2 Homo sapiens Q9BSI4
Pull Down
21044950
Intra
SULT1C2 O00338 TINF2 Homo sapiens Q9BSI4
BiFC
21044950
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SULT1C2 Proteins

Cat. No. Product Name Accession Purity
HY-P71012 SULT1C2 Protein, Human (His) O00338 (M1-L296) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14017 SULT1C2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14018 SULT1C4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20653 Sult1c2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27164 Sult1c2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SULT1C2 MGD MGI:1916333
Macaca mulatta SULT1C2 VGNC VGNC:106228
Rattus norvegicus SULT1C2 RGD RGD:1305885
Felis catus SULT1C2 VGNC VGNC:81231
Canis familiaris SULT1C2 VGNC VGNC:46977
Others SULT1C2 NCBI