SULT2A1 - sulfotransferase family 2A member 1 Gene

Also Known as HST; ST2; STD; hSTa; DHEAS; ST2A1; ST2A3; DHEA-ST; SULT2A3; DHEA-ST8

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6822

About SULT2A1

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:47,870,467-47,886,315 (from NCBI)

This gene has 1 transcript (splice variant), 781 orthologues and 12 paralogues. Biased expression in liver (RPKM 300.0), adrenal (RPKM 86.0) and 2 other tissues.

Summary

This gene encodes a member of the sulfotransferase family. Sulfotransferases aid in the metabolism of drugs and endogenous compounds by converting these substances into more hydrophilic water-soluble sulfate conjugates that can be easily excreted. This protein catalyzes the sulfation of Steroids and bile acids in the liver and adrenal glands, and may have a role in the inherited adrenal androgen excess in women with polycystic ovary syndrome. [provided by RefSeq, Mar 2010]

SULT2A1 Products (1)

mRNA	Protein	Name
NM_003167.4	NP_003158.2	sulfotransferase 2A1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 3'-phosphoadenosine 5'-phosphosulfate binding	IDA IDA: Inferred from direct assay	10854859	GOA
enables alcohol sulfotransferase activity	IDA IDA: Inferred from direct assay	7854148	GOA
enables bile-salt sulfotransferase activity	IDA IDA: Inferred from direct assay	1588921	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21988832	GOA
enables steroid sulfotransferase activity	IDA IDA: Inferred from direct assay	23207770	GOA
enables steroid sulfotransferase activity	IMP IMP: Inferred from mutant phenotype	29671343	GOA
enables sulfotransferase activity	IDA IDA: Inferred from direct assay	19548878	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in 3'-phosphoadenosine 5'-phosphosulfate metabolic process	IDA IDA: Inferred from direct assay	23207770	GOA
involved in cholesterol metabolic process	IDA IDA: Inferred from direct assay	19589875	GOA
involved in ethanol catabolic process	IDA IDA: Inferred from direct assay	23207770	GOA
involved in steroid metabolic process	IDA IDA: Inferred from direct assay	1588921	GOA
involved in steroid metabolic process	IMP IMP: Inferred from mutant phenotype	29671343	GOA
acts upstream of or within sulfation	IDA IDA: Inferred from direct assay	19548878	GOA
involved in sulfation	IDA IDA: Inferred from direct assay	20056724	GOA
involved in thyroid hormone metabolic process	IDA IDA: Inferred from direct assay	10199779	GOA
involved in xenobiotic metabolic process	IDA IDA: Inferred from direct assay	7854148	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	2268288	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SULT2A1 Protein Structure

Sulfotransfer_1

0
100
200
285 a.a.

Protein Preferred Names	Protein Names
sulfotransferase 2A1	alcohol/hydroxysteroid sulfotransferase

SULT2A1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SULT2A1	Q06520	SULT1B1	Homo sapiens	O43704	Y2H Prey Pooling	32296183
Intra	SULT2A1	Q06520	SULT1B1	Homo sapiens	O43704	Y2H Array	32296183
Intra	SULT2A1	Q06520	STAT3	Homo sapiens	P40763	Y2H	21988832
Intra	SULT2A1	Q06520	NIF3L1	Homo sapiens	Q9GZT8	Validated Y2H	32296183
Intra	SULT2A1	Q06520	NIF3L1	Homo sapiens	Q9GZT8	Y2H Array	32296183
Intra	SULT2A1	Q06520	NIF3L1	Homo sapiens	Q9GZT8	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SULT2A1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71343	SULT2A1 Protein, Human (His)	Q06520 (S2-E285)	≥ 95%, as determined by reducing SDS-PAGE.

SULT2A1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82116	Sulfotransferase 2A1 Antibody (YA1861)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Mixed Epithelial Stromal Tumour
Adrenal Cortical Adenoma	Adrenocortical Adenoma Adenoma Adrenocortical
Polycystic Ovary Syndrome	Polycystic Ovarian Syndrome Pcos Polycystic Ovarian Disease Polycystic Ovaries Stein-Leventhal Syndrome Multicystic Ovaries Polycystic Ovary Sclerocystic Ovaries Sclerocystic Ovary Syndrome Stein-Leventhal Synd. Cystic Disease Of Ovaries Cystic Disease Of Ovary Pco Pcod Sclerocystic Ovarian Degeneration Polycystic Ovary Syndrome, Susceptibility To Pcos - [Polycystic Ovary Syndrome] Polycystic Ovary Nos Pco - [Polycystic Ovary]
Conn'S Syndrome	Cushing Syndrome Hyperaldosteronism Primary Hyperaldosteronism Hypercortisolism Primary Aldosteronism Cushing'S Syndrome Adrenal Gland Hyperfunction Conn Syndrome Hyperadrenalism Ectopic Acth Syndrome Hyperadrenocorticism Cushing Disease Cushing'S Disease Adrenal Cortex Adenoma Corticotroph Pituitary Adenoma Pituitary Corticotroph Micro-Adenoma Pituitary-Dependent Cushing Syndrome Pituitary Acth Hypersecretion Acth Syndrome, Ectopic Acth-Secreting Pituitary Adenoma Adrenal Hyperfunction Resulting From Pituitary Acth Excess Ectopic Adrenocorticotropic Hormone Syndrome Nodular Primary Adrenocortical Dysplasia Pituitary Dependent Cushing Syndrome Pituitary Cushing Syndrome Pituitary-Dependant Cushing Syndrome Pituitary-Dependant Hypercortisolism Pituitary-Dependant Hypercortisolism Disorder Aldosteronism Primary Acth Syndrome Ectopic Adrenal Cushing'S Syndrome Adrenal Cortical Adenoma Cushing Syndrome Nos Cortisol Hypersecretion Corticoadrenal Hypersecretion Cushing Syndrome Secondary To Ectopic Acth-Secretion Ectopic Cushing Syndrome Hypercortisolism Due To Nonpituitary Tumour Ectopic Acth - [Adrenocorticotropic Hormone] Secretion Ectopic Acth - [Adrenocorticotropic Hormone] Secretion Causing Cushing Syndrome Idiopathic Aldosteronism Aldosteronism Primary Aldosteronism Due To Bilateral Adrenal Hyperplasia Primary Aldosteronism Due To Adrenal Hyperplasia
Cholangitis, Primary Sclerosing	Primary Sclerosing Cholangitis PSC Sclerosing Cholangitis Cholangitis, Sclerosing Cholangitis Primary Sclerosing Psc - [Primary Sclerosing Cholangitis]
Cortisone Reductase Deficiency	11-Alpha Beta-Hydroxysteroid Dehydrogenase Type I Deficiency Of Cortrd Hsd 11b1 Deficiency
Asperger Syndrome	Asperger Disorder Asperger Syndrome, Susceptibility To
Adrenal Cortical Carcinoma	Adrenocortical Carcinoma Adrenal Cortex Carcinoma Carcinoma Of The Adrenal Cortex Acc Adrenocortical Cancer Carcinoma Adrenocortical
Adult Hepatocellular Carcinoma	Adult Primary Hepatocellular Carcinoma Adult Hepatoma Adult Hcc
Lipoid Congenital Adrenal Hyperplasia	Congenital Adrenal Hyperplasia Congenital Lipoid Adrenal Hyperplasia Due To Star Deficency Congenital Lipoid Adrenal Hyperplasia Lipoid Cah Lipoid Adrenal Hyperplasia Adrenal Hyperplasia 1 Cah Clah LCAH Adrenal Hyperplasia I Lipoid Hyperplasia, Congenital, Of Adrenal Cortex With Male Pseudohermaphroditism Congenital Adrenal Hyperplasia Lipoid Adrenal Hyperplasia, Congenital Congenital Adrenal Hyperplasia, Lipoid AH1 Congenital Lipoid Hyperplasia Of Adrenal Cortex With Male Pseudohermaphroditism Adrenal Hyperplasia Congenital Hyperplasia, Adrenal, Lipoid, Congenital Congenital Adrenogenital Disorders Associated With Enzyme Deficiency Congenital Adrenal Cortical Hyperplasia Congenital Adrenal Gland Hyperplasia Congenital Adrenogenital Syndrome Congenital Hyperadrenocorticism Congenital Adrenogenitalism Congenital Female Adrenal Pseudohermaphroditism
Intrahepatic Cholestasis Of Pregnancy	Recurrent Intrahepatic Cholestasis Of Pregnancy Gravidic Intrahepatic Cholestasis Pregnancy-Related Cholestasis Icp Pregnancy Related Cholestasis Cholestasis, Intrahepatic Of Pregnancy Familial Intrahepatic Cholestasis Of Pregnancy Familial Recurrent Intrahepatic Cholestasis Of Pregnancy Ricp Obstetric Cholestasis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14020	SULT2A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14021	SULT2B1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-48813	Glycoursodeoxycholic acid 3-sulfate	Inhibitor	/	Unkown
HY-RS19554	Sult2b1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20654	Sult2a1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26050	Sult2b1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27165	Sult2a1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SULT2A1	RGD	RGD:621337
Macaca mulatta	SULT2A1	VGNC	VGNC:78053
Others	SULT2A1	NCBI