Cdkal1 - CDK5 regulatory subunit associated protein 1-like 1 Gene

Also Known as 1190005B03Rik; 6620401C13Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 68916

Summary

Enables N6-threonylcarbomyladenosine methylthiotransferase activity. Acts upstream of or within maintenance of translational fidelity and tRNA methylthiolation. Located in rough endoplasmic reticulum. Is expressed in olfactory epithelium and testis. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in diabetes mellitus; gestational diabetes; and type 2 diabetes mellitus. Orthologous to human CDKAL1 (CDK5 regulatory subunit associated protein 1 like 1). [provided by Alliance of Genome Resources, Apr 2022]

Cdkal1 Products (2)

mRNA Protein Name
NM_001308486.1 NP_001295415.1 threonylcarbamoyladenosine tRNA methylthiotransferase isoform 2
NM_144536.3 NP_653119.1 threonylcarbamoyladenosine tRNA methylthiotransferase isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables N6-threonylcarbomyladenosine methylthiotransferase activity IMP
IMP: Inferred from mutant phenotype
21841312 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within maintenance of translational fidelity IMP
IMP: Inferred from mutant phenotype
21841312 MGI
acts upstream of or within tRNA methylthiolation IMP
IMP: Inferred from mutant phenotype
21841312 MGI
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
21151568 MGI
located in rough endoplasmic reticulum IDA
IDA: Inferred from direct assay
21841312 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

threonylcarbamoyladenosine tRNA methylthiotransferase

  • tRNA-t(6)A37 methylthiotransferase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02404 CDKAL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21102 Cdkal1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27621 Cdkal1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdkal1 NCBI NCBI:54901