Tpmt - thiopurine S-methyltransferase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 690050

Summary

Predicted to enable S-adenosyl-L-methionine binding activity and thiopurine S-methyltransferase activity. Involved in response to testosterone. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; alopecia; leukopenia; and thiopurine S-methyltransferase deficiency. Orthologous to human TPMT (thiopurine S-methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Tpmt Products (1)

mRNA Protein Name
NM_001395670.1 NP_001382599.1 thiopurine S-methyltransferase

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
3994729 RGD
involved in response to testosterone IEP
IEP: Inferred from expression pattern
1897245 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

thiopurine S-methyltransferase

  • thiopurine methyltransferase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14940 TPMT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-134062 7-Methyl-6-mercaptopurine / Unkown
HY-RS18794 Tpmt Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25283 Tpmt Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tpmt NCBI NCBI:7172