TCN1 - transcobalamin 1 Gene

Homo sapiens

Also known as HC; TC1; TCI; TC-1

Gene ID: 6947 | Gene type: protein coding

About TCN1

Cytogenetic location: 11q12.1 Genomic coordinates (GRCh38): 11:59,852,808-59,866,487 (from NCBI)

This gene has 5 transcripts (splice variants), 97 orthologues and 2 paralogues. Biased expression in salivary gland (RPKM 166.7), gall bladder (RPKM 102.9) and 3 other tissues.

Summary

This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This protein is a major constituent of secondary granules in neutrophils and facilitates the transport of cobalamin into cells. [provided by RefSeq, Jul 2008]

TCN1 Products(1)

mRNA	Protein	Name
NM_001062.4	NP_001053.2	transcobalamin-1 precursor

TCN1 Protein Structure

Cobalamin_bind

DUF4430

0
100
200
300
400
433 a.a.

Protein Preferred Names

Protein Names

transcobalamin-1

haptocorin

Recombinant TCN1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71789	TCN1 Protein, Human (P.pastoris, His)	P20061 (24E-433Y)	≥95%

Related Diseases

Diseases

Alias

Transcobalamin I Deficiency

Tcn1 Deficiency	Cobalamin Pseudodeficiency Due To Transcobalamin Deficiency
Cobalamin R Binder Protein Deficiency	Transcobalamin 1 Deficiency
Haptocorrin Deficiency	Tci Deficiency
Transcobalamin-1 Deficiency

Vitamin B12 Deficiency

Cobalamin Deficiency	Hypocobalaminemia
Vitamin B 12 Deficiency	Cyanocobalamin Deficiency
Deficiency Of Vitamin B12

Vitamin Metabolic Disorder

Transcobalamin Ii Deficiency

TCN2 DEFICIENCY	Tc Ii Deficiency
Transcobalamin Deficiency	Tc Deficiency
Inherited Deficiency Of Transcobalamin

Megaloblastic Anemia

Imerslund-Grasbeck Syndrome	Igs
Defect Of Enterocyte Intrinsic Factor Receptor	Enterocyte Cobalamin Malabsorption
Familial Megaloblastic Anemia	Megaloblastic Anemia 1
Selective Cobalamin Malabsorption With Proteinuria	Imerslund-Gräsbeck Syndrome
Anemia, Megaloblastic	Grasbeck-Imerslund Syndrome
Megaloblastic Anaemia	Mga1 Norwegian Type
Recessive Hereditary Megaloblastic Anaemia 1	Recessive Hereditary Megaloblastic Anemia 1
Rh-Mga1	Gräsbeck-Imerslund Disease
Pernicious Anemia, Juvenile, Due To Selective Intestinal Malabsorption Of Vitamin B12, With Proteinuria	Juvenile Pernicious Anemia With Proteinuria Due To Selective Intestinal Malabsorption Of Vitamin B12
Anemia Megaloblastic	Megaloblastic Anemia Due To Inborn Errors Of Metabolism
3-@Methylglutaconic Aciduria, Type I

Tropical Sprue

Tropical Steatorrhea	Tropical Enteropathy
Sprue, Tropical	Sprue - Tropical
Idiopathic Tropical Malabsorption Syndrome	Tropical Steatorrhoea
Tropical Diarrhoea	Ts - [Tropical Sprue]
Psilosis	Sprue Nos

Autoimmune Lymphoproliferative Syndrome

ALPS	Canale-Smith Syndrome
Autoimmune Lymphoproliferative Syndrome, Type Ia	Autoimmune Lymphoproliferative Syndrome, Type Ib
Autoimmune Lymphoproliferative Syndrome Type 1, Autosomal Dominant	Css
Autoimmune Lymphoproliferative Syndrome, Type 1b	Autoimmune Lymphoproliferative Syndrome, Type 1a
Autoimmune Lymphoproliferative Syndrome, Type I, Autosomal Dominant	Fas Deficiency
Autoimmune Lymphoproliferative Syndrome 1a	ALPS1A
Autoimmune Lymphoproliferative Syndrome Type Ia	Autoimmune Lymphoproliferative Syndrome 1b
ALPS1B	Autoimmune Lymphoproliferative Syndrome Type Ib

Pernicious Anemia

Anemia, Pernicious	Anemia Pernicious
Pernicious Anaemia	Addison'S Anaemia
Biermer'S Anaemia	Biermer'S Anemia
Acquired Pernicious Anemia	Addison-Biermer Anemia
Addisonian Anemia	Biermer Anemia
Biermer'S Disease	Juvenile Onset Pernicious Anemia
Biermer Disease	Biermer-Addison Disease

Neural Tube Defects

Spina Bifida	Neural Tube Defect
NTD	Neural Tube Defects, Susceptibility To
Spinal Dysraphism	Spina Bifida, Susceptibility To
Rachischisis	Cleft Spine
Open Spine	Hydrocele Spinalis
Neural Tube Defect Nos	Sb - [Spina Bifida]
Spinal Hernia Nos	Spinal Fissure Nos

Diphyllobothriasis

Diphyllobothrium Infection	Fish Tapeworm
Bothriocephalosis	Infection By Bothriocephalus
Fish Tapeworm Infection	Dibothriocephalus Anaemia
Dibothriocephaliasis	Broad Tapeworm Infection
Bothriocephaliasis	Dibothriocephalus
Intestinal Diphyllobothriasis	Diphyllobothrium Infestation
Dibothriocephalus Infestation	Bothriocephalus Infestation
Adult Diphyllobothrium Infection	Tapeworm Anaemia
Infection By Diphyllobothrium Larvae

Blind Loop Syndrome

Bacterial Overgrowth Syndrome

Fibrolamellar Carcinoma

Fibrolamellar Hepatocellular Carcinoma	Fhcc
Fibrolamellar Hepatocarcinoma	Hepatocellular Carcinoma, Fibrolamellar
Oncocytic Hepatocellular Tumor	Eosinophilic Glassy Cell Hepatoma
Eosinophilic Hepatocellular Carcinoma With Lamellar Fibrosis	Fl-Hcc
Fibrolamellar Oncocytic Hepatoma	Hepatocellular Carcinoma With Increased Stromal Fibrosis
Polygonal Cell Hepatocellular Carcinoma With Fibrous Stroma

Methylmalonic Acidemia

Methylmalonic Aciduria	Mma
Acidemia, Methylmalonic	Isolated Methylmalonic Acidemia

Leukemia, Chronic Myeloid

Chronic Myeloid Leukemia	Chronic Myelogenous Leukemia
CML	Chronic Granulocytic Leukemia
Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib	Chronic Myeloid Leukaemia
Chronic Granulocytic Leukaemia	Chronic Myelogenous Leukaemia
Myeloid Leukemia, Chronic	Leukemia, Chronic Myelogenous
Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic	Cml - Chronic Myelogenous Leukemia
Cgl	Chronic Myelocytic Leukemia
Leukemia, Chronic Myeloid, Atypical	ACML
Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative	Myeloid Leukemia Chronic
Leukemia, Myeloid, Chronic	Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative
Cml- [Chronic Myeloid Leukaemia]	Cgl - [Chronic Granulocytic Leukaemia]
Chronic Myelocytic Leukaemia

Deficiency Anemia

Anemia	Deficiency Anemias
Anaemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14318	TCN1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TCN1	NCBI
Rattus norvegicus	TCN1	NCBI