Cad - carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase Gene

Also Known as Cpad; 2410008J01Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 69719

Summary

Enables aspartate carbamoyltransferase activity; carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity; and dihydroorotase activity. Involved in 'de novo' UMP biosynthetic process. Predicted to be located in nuclear matrix and nucleoplasm. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; brain; branchial arch; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 50. Orthologous to human CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase). [provided by Alliance of Genome Resources, Apr 2022]

Cad Products (5)

mRNA Protein Name
NM_001289522.2 NP_001276451.1 CAD protein isoform 2
NM_001289523.2 NP_001276452.1 CAD protein isoform 3
NM_001403399.1 NP_001390328.1 CAD protein isoform 4
NM_001403400.1 NP_001390329.1 CAD protein isoform 5
NM_023525.3 NP_076014.1 CAD protein isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables aspartate carbamoyltransferase activity IDA
IDA: Inferred from direct assay
5125237 MGI
enables carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity IDA
IDA: Inferred from direct assay
5125237 MGI
enables carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity IMP
IMP: Inferred from mutant phenotype
33771897 MGI
enables dihydroorotase activity IMP
IMP: Inferred from mutant phenotype
33771897 MGI
Biological Process GO Annotation Evidence References Source
involved in 'de novo' UMP biosynthetic process IMP
IMP: Inferred from mutant phenotype
33771897 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

CAD protein

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-109160 Rimtuzalcap Activator 99.27% Phase 2

Pre-clinical Phase

Bioactive Molecules (19)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-139580 Plazinemdor Agonist 96.61% Unkown
HY-128912 Arborinine Inhibitor 99.87% Unkown
HY-RS16239 Acod1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-123494 BRD0418 Modulator 99.22% Unkown
HY-124609 CAD031 99.39% Unkown
HY-137959 Telmisartan acyl-β-D-glucuronide Substrate 94.68% Unkown
HY-N1753 3-(4-Hydroxyphenyl)-1-propanol 98.70% Unkown
HY-164466 CAD204520 Inhibitor 99.22% Unkown
HY-164466A CAD204520 dihydrochloride Inhibitor 99.26% Unkown
HY-RS01818 CAD Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-103406 PNU-177864 / Unkown
HY-103406A PNU-177864 hydrochloride / Unkown
HY-179354 AP21998 Ligand / Unkown
HY-RS00172 ACOD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03709 DFFB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-128446 CAY10781 Inhibitor 98.04% Unkown
HY-N18868 1-Palmitoyl-2-capryloyl-sn-glycero-3-phosphocholine / Unkown
HY-RS17214 Cad Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23666 Cad Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99301 Lokivetmab Inhibitor 99.34% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cad NCBI NCBI:790