2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. Plazinemdor

Plazinemdor  (Synonyms: CAD-9303)

Cat. No.: HY-139580 Purity: 98.68%
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Plazinemdor is a N-methyl-D-aspartate(NMDA) receptor positive allosteric modulator. Plazinemdor can be uses in the research of psychiatric, neurological, and neurodevelopmental disorders, as well as diseases of the nervous system..

For research use only. We do not sell to patients.

Plazinemdor Chemical Structure

Plazinemdor Chemical Structure

CAS No. : 2378285-59-5

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 385 In-stock
Solution
10 mM * 1 mL in DMSO USD 385 In-stock
Solid
5 mg USD 350 In-stock
10 mg USD 600 In-stock
25 mg USD 1250 In-stock
50 mg USD 1950 In-stock
100 mg USD 3200 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Plazinemdor is a N-methyl-D-aspartate(NMDA) receptor positive allosteric modulator. Plazinemdor can be uses in the research of psychiatric, neurological, and neurodevelopmental disorders, as well as diseases of the nervous system[1]..

IC50 & Target

NMDA Receptor

 

Molecular Weight

432.85

Formula

C21H19ClF2N4O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1C2=C(N=CN1CC(N3CC(C)(C3)F)=O)N(C4CC4)C=C2C5=CC(Cl)=C(F)C=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (231.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3103 mL 11.5513 mL 23.1027 mL
5 mM 0.4621 mL 2.3103 mL 4.6205 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3103 mL 11.5513 mL 23.1027 mL 57.7567 mL
5 mM 0.4621 mL 2.3103 mL 4.6205 mL 11.5513 mL
10 mM 0.2310 mL 1.1551 mL 2.3103 mL 5.7757 mL
15 mM 0.1540 mL 0.7701 mL 1.5402 mL 3.8504 mL
20 mM 0.1155 mL 0.5776 mL 1.1551 mL 2.8878 mL
25 mM 0.0924 mL 0.4621 mL 0.9241 mL 2.3103 mL
30 mM 0.0770 mL 0.3850 mL 0.7701 mL 1.9252 mL
40 mM 0.0578 mL 0.2888 mL 0.5776 mL 1.4439 mL
50 mM 0.0462 mL 0.2310 mL 0.4621 mL 1.1551 mL
60 mM 0.0385 mL 0.1925 mL 0.3850 mL 0.9626 mL
80 mM 0.0289 mL 0.1444 mL 0.2888 mL 0.7220 mL
100 mM 0.0231 mL 0.1155 mL 0.2310 mL 0.5776 mL
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Plazinemdor Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Plazinemdor2378285-59-5CAD-9303CAD9303CAD 9303iGluRIonotropic glutamate receptorsInhibitorinhibitorinhibit

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