Trim32 - tripartite motif-containing 32 Gene

Also Known as 3f3; BBS11; Zfp117; 1810045E12Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 69807

Summary

Enables several functions, including identical protein binding activity; translation initiation factor binding activity; and ubiquitin protein Ligase activity. Involved in several processes, including positive regulation of NF-kappaB transcription factor activity; positive regulation of cell differentiation; and response to tumor necrosis factor. Acts upstream of or within several processes, including positive regulation of cytokine-mediated signaling pathway; positive regulation of macromolecule metabolic process; and protein ubiquitination. Located in nucleus and striated muscle Myosin thick filament. Is expressed in genitourinary system. Used to study autosomal recessive limb-girdle muscular dystrophy type 2H. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome; Bardet-Biedl syndrome 11; autosomal recessive limb-girdle muscular dystrophy type 2H; and muscular dystrophy. Orthologous to human TRIM32 (tripartite motif containing 32). [provided by Alliance of Genome Resources, Apr 2022]

Trim32 Products (2)

mRNA Protein Name
NM_001161782.1 NP_001155254.1 E3 ubiquitin-protein ligase TRIM32
NM_053084.2 NP_444314.2 E3 ubiquitin-protein ligase TRIM32

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA binding IDA
IDA: Inferred from direct assay
19269368 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
11331580 MGI
enables myosin binding IPI
IPI: Inferred from physical interaction
16243356 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16816390 MGI
enables translation initiation factor binding IPI
IPI: Inferred from physical interaction
16243356 MGI
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
16243356 MGI
enables ubiquitin-protein transferase activity IMP
IMP: Inferred from mutant phenotype
22299041 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within actin ubiquitination IDA
IDA: Inferred from direct assay
16243356 MGI
acts upstream of or within axon development IMP
IMP: Inferred from mutant phenotype
19155210 MGI
involved in fat cell differentiation IEP
IEP: Inferred from expression pattern
17379567 MGI
acts upstream of or within muscle cell cellular homeostasis IMP
IMP: Inferred from mutant phenotype
21775502 MGI
involved in negative regulation of fibroblast proliferation IEP
IEP: Inferred from expression pattern
19269368 MGI
involved in positive regulation of NF-kappaB transcription factor activity IDA
IDA: Inferred from direct assay
16816390 MGI
involved in positive regulation of cell motility IDA
IDA: Inferred from direct assay
18632609 MGI
acts upstream of or within positive regulation of chemokine (C-C motif) ligand 20 production IMP
IMP: Inferred from mutant phenotype
20054338 MGI
acts upstream of or within positive regulation of interleukin-17-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
20054338 MGI
involved in positive regulation of neurogenesis IDA
IDA: Inferred from direct assay
19269368 MGI
involved in positive regulation of neuron differentiation IDA
IDA: Inferred from direct assay
19269368 MGI
acts upstream of or within positive regulation of protein catabolic process IDA
IDA: Inferred from direct assay
16243356 MGI
involved in positive regulation of protein catabolic process IDA
IDA: Inferred from direct assay
19269368 MGI
acts upstream of or within positive regulation of striated muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
22299041 MGI
acts upstream of or within positive regulation of tumor necrosis factor-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
20054338 MGI
acts upstream of or within protein polyubiquitination IMP
IMP: Inferred from mutant phenotype
22299041 MGI
acts upstream of or within protein ubiquitination IDA
IDA: Inferred from direct assay
16243356 MGI
involved in protein ubiquitination IDA
IDA: Inferred from direct assay
19269368 MGI
involved in response to UV IDA
IDA: Inferred from direct assay
16816390 MGI
involved in response to tumor necrosis factor IDA
IDA: Inferred from direct assay
16816390 MGI
acts upstream of or within tissue homeostasis IMP
IMP: Inferred from mutant phenotype
19155210 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
11331580 MGI
located in striated muscle myosin thick filament IDA
IDA: Inferred from direct assay
16243356 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase TRIM32

  • RING-type E3 ubiquitin transferase TRIM32

  • bM468K2.2 (tripartite motif protein 32)

  • tripartite motif protein 32

  • tripartite motif-containing protein 32

  • zinc finger protein 117

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15037 TRIM32 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21208 Trim32 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27724 Trim32 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Trim32 NCBI NCBI:22954