Smc4 - structural maintenance of chromosomes 4 Gene

Also Known as SMC-4; Smc4l1; 2500002A22Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 70099

Summary

Enables chromatin binding activity and single-stranded DNA binding activity. Acts upstream of or within kinetochore organization; meiotic chromosome condensation; and meiotic chromosome segregation. Located in chromosome, centromeric region. Part of condensin complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human SMC4 (structural maintenance of chromosomes 4). [provided by Alliance of Genome Resources, Apr 2022]

Smc4 Products (2)

mRNA Protein Name
NM_001356976.1 NP_001343905.1 structural maintenance of chromosomes protein 4 isoform 2
NM_133786.4 NP_598547.1 structural maintenance of chromosomes protein 4 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chromatin binding IDA
IDA: Inferred from direct assay
23531880 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
20139420 MGI
enables single-stranded DNA binding IDA
IDA: Inferred from direct assay
20139420 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within kinetochore organization IMP
IMP: Inferred from mutant phenotype
21795393 MGI
acts upstream of or within meiotic chromosome condensation IMP
IMP: Inferred from mutant phenotype
21795393 MGI
acts upstream of or within meiotic chromosome segregation IMP
IMP: Inferred from mutant phenotype
21795393 MGI
involved in positive regulation of chromosome segregation IMP
IMP: Inferred from mutant phenotype
25474630 MGI
involved in positive regulation of chromosome separation IMP
IMP: Inferred from mutant phenotype
21795393 MGI
Cellular Component GO Annotation Evidence References Source
located in chromosome, centromeric region IDA
IDA: Inferred from direct assay
26919979 MGI
located in condensed nuclear chromosome IDA
IDA: Inferred from direct assay
25474630 MGI
part of condensin complex IDA
IDA: Inferred from direct assay
21795393 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

structural maintenance of chromosomes protein 4

  • SMC protein 4

  • SMC4 structural maintenance of chromosomes 4-like 1

  • XCAP-C homolog

  • chromosome-associated polypeptide C

Smc4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Smc4 Q8CG47 Yy1 Mus musculus Q00899
Anti Bait CoIP
23531880
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13420 SMC4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20820 Smc4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27334 Smc4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Smc4 NCBI NCBI:10051