THBS2 - thrombospondin 2 Gene

Also Known as TSP2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7058

About THBS2

Cytogenetic location: 6q27 Genomic coordinates (GRCh38): 6:169,215,785-169,253,846 (from NCBI)

This gene has 15 transcripts (splice variants), 276 orthologues, 5 paralogues and is associated with 1 phenotype. Broad expression in gall bladder (RPKM 49.1), endometrium (RPKM 31.3) and 18 other tissues.

Summary

The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein has been shown to function as a potent inhibitor of tumor growth and angiogenesis. Studies of the mouse counterpart suggest that this protein may modulate the cell surface properties of mesenchymal cells and be involved in cell adhesion and migration. [provided by RefSeq, Jul 2008]

THBS2 Products (5)

mRNA Protein Name
NM_001381939.1 NP_001368868.1 thrombospondin-2 isoform 2 precursor
NM_001381940.1 NP_001368869.1 thrombospondin-2 isoform 3 precursor
NM_001381941.1 NP_001368870.1 thrombospondin-2 isoform 4 precursor
NM_001381942.1 NP_001368871.1 thrombospondin-2 isoform 5
NM_003247.5 NP_003238.2 thrombospondin-2 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19818485 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of angiogenesis IDA
IDA: Inferred from direct assay
20714802 GOA
Cellular Component GO Annotation Evidence References Source
located in platelet alpha granule IDA
IDA: Inferred from direct assay
1737102 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

THBS2 Protein Structure

VWC

VWC: von Willebrand factor type C domain (320 - 374)

TSP_1

TSP_1: Thrombospondin type 1 domain (385 - 430)

TSP_1

TSP_1: Thrombospondin type 1 domain (441 - 491)

TSP_1

TSP_1: Thrombospondin type 1 domain (498 - 548)

EGF_CA

EGF_CA: Calcium-binding EGF domain (590 - 630)

EGF_3

EGF_3: EGF domain (652 - 691)

TSP_3

TSP_3: Thrombospondin type 3 repeat (729 - 764)

TSP_3

TSP_3: Thrombospondin type 3 repeat (764 - 787)

TSP_3

TSP_3: Thrombospondin type 3 repeat (789 - 823)

TSP_3

TSP_3: Thrombospondin type 3 repeat (824 - 846)

TSP_3

TSP_3: Thrombospondin type 3 repeat (847 - 884)

TSP_3

TSP_3: Thrombospondin type 3 repeat (886 - 920)

TSP_3

TSP_3: Thrombospondin type 3 repeat (921 - 952)

TSP_C

TSP_C: Thrombospondin C-terminal region (974 - 1171)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1172 a.a.
Protein Preferred Names Protein Names

thrombospondin-2

THBS2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
THBS2 P35442 Cacna2d1 Rattus norvegicus P54290
Anti Tag CoIP
19818485
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant THBS2 Proteins

Cat. No. Product Name Accession Purity
HY-P78725 Thrombospondin-2 Protein, Human (HEK293, His) P35442-1 (G19-I1172) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Intervertebral Disc Disease

  • Lumbar Disc Disease

  • Intervertebral Disc Disorder

  • IDD

  • Lumbar Disc Herniation

  • Lumbar Disc Degeneration

  • Intervertebral Disc Disease, Susceptibility To

  • Lumbar Disc Herniation, Susceptibility To

  • Lumbar Disc Disease, Susceptibility To

  • Intervertebral Disc Degeneration

  • Discogenic Disease

  • Discogenic Disorder

  • Disorder Of Intervertebral Disc

  • Intervertebral Disk Degeneration

  • Intervertebral Disk Disease

  • Ldd

  • Ldh

  • Lumbar Disc Degeneration, Susceptibility To

  • Degeneration Of Lumbar Intervertebral Disc

  • Intervertebral Disk Displacement
Back Pain
Spinal Stenosis

  • Lumbar Spinal Stenosis

  • Cervical Spinal Stenosis

  • Spinal Stenosis Of Lumbar Region

  • Spinal Stenosis In Cervical Region

  • Spinal Canal Stenosis
Ehlers-Danlos Syndrome

  • Eds

  • Cutis Hyperelastica

  • Elastic Skin

  • Ehlers-Danlos Syndromes

  • Ed Syndrome

  • Ehlers Danlos Syndrome

  • Ehlers Danlos Disease

  • Eds - [Ehlers-Danlos Syndrome]
Intestinal Schistosomiasis

  • Schistosomiasis Japonica

  • Schistosomiasis Mansoni

  • Katayama Fever

  • Schistosoma Japonicum Infection

  • Schistosoma Mansoni Infectious Disease

  • Schistosomiasis
Urinary Schistosomiasis

  • Schistosoma Haematobium Infection

  • Schistosoma Hematobium Infection

  • Schistosomiasis Due To Schistosoma Haematobium

  • Bladder Schistosomiasis

  • Cystitis With Bilharziasis

  • Schistosoma Haematobium

  • Schistosoma Hematobium Infectious Disease

  • Schistosomiasis Of Bladder

  • Vesical Schistosomiasis

  • Schistosomiasis Urinary

  • Schistosomiasis Haematobia

  • Genitourinary Bilharziasis

  • Genitourinary Tract Schistosomiasis

  • Schistosomiasis Due To Schistosoma Haematobium [Urinary Schistosomiasis]

  • Haematochyluria In Schistosomiasis

  • Infection Due To Schistosoma Matthei
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Myocardial Infarction

  • Heart Attack

  • Myocardial Infarction, Susceptibility To

  • Myocardial Infarction 1

  • Myocardial Infarction, Protection Against

  • Myocardial Infarction, Decreased Susceptibility To

  • Myocardial Infarction, Decreased

  • Myocardial Infarct

  • MCI1

  • Premature Myocardial Infarction

  • Myocardial Infarction, Susceptibility To, Type 1
Type 2 Diabetes Mellitus

  • Insulin Resistance

  • NIDDM

  • Type 2 Diabetes

  • Diabetes Mellitus, Non-Insulin-Dependent

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14480 THBS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23968 Thbs2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17511 Thbs2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus THBS2 VGNC VGNC:66155
Bos taurus THBS2 VGNC VGNC:35829
Mus musculus THBS2 MGD MGI:98738
Macaca mulatta THBS2 VGNC VGNC:104433
Canis familiaris THBS2 VGNC VGNC:47336
Rattus norvegicus THBS2 RGD RGD:1310979
Others THBS2 NCBI