Spag9 - sperm associated antigen 9 Gene

Also Known as JLP; Jip4; syd1; JIP-4; JSAP2; JSAP2a; Mapk8ip4; 3110018C07Rik; 4733401I23Rik; 4831406C20Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 70834

Summary

Enables several functions, including MAP-kinase scaffold activity; Kinesin binding activity; and protein kinase binding activity. Acts upstream of or within several processes, including JNK cascade; positive regulation of MAPK cascade; and positive regulation of neuron differentiation. Located in perinuclear region of cytoplasm. Is expressed in central nervous system; dorsal root ganglion; retina; and trigeminal nerve. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and liver cirrhosis. Orthologous to human SPAG9 (sperm associated antigen 9). [provided by Alliance of Genome Resources, Apr 2022]

Spag9 Products (8)

mRNA Protein Name
NM_001025428.2 NP_001020599.1 C-Jun-amino-terminal kinase-interacting protein 4 isoform 2
NM_001025429.2 NP_001020600.1 C-Jun-amino-terminal kinase-interacting protein 4 isoform 3
NM_001025430.2 NP_001020601.1 C-Jun-amino-terminal kinase-interacting protein 4 isoform 4
NM_001199203.2 NP_001186132.1 C-Jun-amino-terminal kinase-interacting protein 4 isoform 5
NM_001199204.2 NP_001186133.1 C-Jun-amino-terminal kinase-interacting protein 4 isoform 6
NM_001199205.2 NP_001186134.1 C-Jun-amino-terminal kinase-interacting protein 4 isoform 7
NM_001363157.1 NP_001350086.1 C-Jun-amino-terminal kinase-interacting protein 4 isoform 8
NM_027569.3 NP_081845.2 C-Jun-amino-terminal kinase-interacting protein 4 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables JUN kinase binding IDA
IDA: Inferred from direct assay
15767678 MGI
enables MAP-kinase scaffold activity IDA
IDA: Inferred from direct assay
15767678 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
15767678 MGI
enables kinesin binding IDA
IDA: Inferred from direct assay
15767678 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12391307 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within positive regulation of MAPK cascade IDA
IDA: Inferred from direct assay
15767678 MGI
acts upstream of or within positive regulation of MAPK cascade IGI
IGI: Inferred from genetic interaction
15767678 MGI
acts upstream of or within positive regulation of neuron differentiation IMP
IMP: Inferred from mutant phenotype
19244314 MGI
acts upstream of or within striated muscle cell differentiation IGI
IGI: Inferred from genetic interaction
20160094 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
15767678 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

C-Jun-amino-terminal kinase-interacting protein 4

  • JNK-associated leucine-zipper protein

  • JNK-interacting leucine zipper

  • JNK-interacting protein 4

  • JNK/SAPK-associated protein 2

  • mitogen-activated protein kinase 8-interacting protein 4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13627 SPAG9 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22820 Spag9 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29335 Spag9 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Spag9 NCBI NCBI:9043