Sulf2 - sulfatase 2 Gene

Also Known as MSulf-2; mKIAA1247; 2010004N24Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 72043

Summary

Enables N-acetylglucosamine-6-sulfatase activity. Involved in several processes, including esophagus smooth muscle contraction; glomerular filtration; and skeletal system development. Acts upstream of or within several processes, including liver regeneration; positive regulation of canonical Wnt signaling pathway; and regulation of hepatocyte proliferation. Located in plasma membrane. Is expressed in several structures, including embryo mesenchyme; genitourinary system; limb; nervous system; and sensory organ. Orthologous to human SULF2 (sulfatase 2). [provided by Alliance of Genome Resources, Apr 2022]

Sulf2 Products (4)

mRNA Protein Name
NM_001252578.1 NP_001239507.1 extracellular sulfatase Sulf-2 isoform 1 precursor
NM_001252579.1 NP_001239508.1 extracellular sulfatase Sulf-2 isoform 2
NM_001355619.1 NP_001342548.1 extracellular sulfatase Sulf-2 isoform 1 precursor
NM_028072.5 NP_082348.2 extracellular sulfatase Sulf-2 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables N-acetylglucosamine-6-sulfatase activity IMP
IMP: Inferred from mutant phenotype
18687675 MGI
Biological Process GO Annotation Evidence References Source
involved in bone development IGI
IGI: Inferred from genetic interaction
17593974 MGI
involved in cartilage development IMP
IMP: Inferred from mutant phenotype
20479257 MGI
involved in chondrocyte development IMP
IMP: Inferred from mutant phenotype
20479257 MGI
involved in embryonic skeletal system development IGI
IGI: Inferred from genetic interaction
18213582 MGI
involved in esophagus smooth muscle contraction IGI
IGI: Inferred from genetic interaction
17720696 MGI
involved in glial cell-derived neurotrophic factor receptor signaling pathway IDA
IDA: Inferred from direct assay
17720696 MGI
involved in glomerular basement membrane development IGI
IGI: Inferred from genetic interaction
21719793 MGI
involved in glomerular filtration IGI
IGI: Inferred from genetic interaction
21719793 MGI
involved in heparan sulfate proteoglycan metabolic process IMP
IMP: Inferred from mutant phenotype
18687675 MGI
involved in innervation IGI
IGI: Inferred from genetic interaction
17720696 MGI
involved in kidney development IGI
IGI: Inferred from genetic interaction
17593974 MGI
acts upstream of or within liver regeneration IMP
IMP: Inferred from mutant phenotype
23740243 MGI
involved in negative regulation of fibroblast growth factor receptor signaling pathway IGI
IGI: Inferred from genetic interaction
17593974 MGI
acts upstream of or within positive regulation of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
23740243 MGI
involved in positive regulation of vascular endothelial growth factor production IGI
IGI: Inferred from genetic interaction
21719793 MGI
acts upstream of or within regulation of hepatocyte proliferation IMP
IMP: Inferred from mutant phenotype
23740243 MGI
acts upstream of or within response to wounding IMP
IMP: Inferred from mutant phenotype
23740243 MGI
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
21719793 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

extracellular sulfatase Sulf-2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14012 SULF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20108 Sulf2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26612 Sulf2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sulf2 NCBI NCBI:55959