Tpx2 - TPX2, microtubule-associated Gene

Also Known as DIL2; p100; REPP86; 2610005B21Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 72119

Summary

Enables importin-alpha family protein binding activity and protein kinase binding activity. Involved in mitotic spindle assembly and regulation of mitotic spindle organization. Located in axon hillock and spindle. Is expressed in nephrogenic zone. Orthologous to human TPX2 (TPX2 microtubule nucleation factor). [provided by Alliance of Genome Resources, Apr 2022]

Tpx2 Products (5)

mRNA Protein Name
NM_001141975.1 NP_001135447.1 targeting protein for Xklp2
NM_001141976.1 NP_001135448.1 targeting protein for Xklp2
NM_001141977.1 NP_001135449.1 targeting protein for Xklp2
NM_001141978.1 NP_001135450.1 targeting protein for Xklp2
NM_028109.4 NP_082385.3 targeting protein for Xklp2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables importin-alpha family protein binding IDA
IDA: Inferred from direct assay
26165940 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
19668197 MGI
enables protein kinase binding IPI
IPI: Inferred from physical interaction
18663142 MGI
Biological Process GO Annotation Evidence References Source
involved in mitotic spindle assembly IMP
IMP: Inferred from mutant phenotype
26165940 MGI
involved in regulation of mitotic spindle organization IMP
IMP: Inferred from mutant phenotype
18663142 MGI
Cellular Component GO Annotation Evidence References Source
located in axon hillock IDA
IDA: Inferred from direct assay
19668197 MGI
located in spindle IDA
IDA: Inferred from direct assay
18663142 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

targeting protein for Xklp2

  • TPX2, microtubule-associated protein homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-122236 UMK57 99.51% Unkown
HY-168022 CAM2602 Inhibitor 99.85% Unkown
HY-125956 Aurkin A 98.0% Unkown
HY-RS14959 TPX2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-158038 AurkA allosteric-IN-1 / Unkown
HY-183102 ATC12 / Unkown
HY-RS19965 Tpx2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26468 Tpx2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tpx2 NCBI NCBI:22974