2. Gene
  3. Lrpprc - leucine-rich PPR-motif containing Gene

Lrpprc - leucine-rich PPR-motif containing Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Lsfc; Gp130; Lrp130; 3110001K13Rik

Gene ID: 72416 | Gene type: protein coding

About Lrpprc

Summary

Enables RNA binding activity and single-stranded DNA binding activity. Acts upstream of or within negative regulation of mitochondrial RNA catabolic process and regulation of mitochondrial translation. Located in mitochondrion and nucleus. Part of ribonucleoprotein complex. Is expressed in several structures, including brain; genitourinary system; heart; liver; and skeletal muscle. Human ortholog(s) of this gene implicated in French Canadian Leigh disease and Leigh disease. Orthologous to human LRPPRC (leucine rich pentatricopeptide repeat containing). [provided by Alliance of Genome Resources, Apr 2022]

Lrpprc Products(1)

mRNA Protein Name
NM_028233.2 NP_082509.2 leucine-rich PPR motif-containing protein, mitochondrial precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables RNA binding IDA
IDA: Inferred from direct assay
21880015 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17050673 MGI
enables single-stranded DNA binding IDA
IDA: Inferred from direct assay
12071956 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of mitochondrial RNA catabolic process IMP
IMP: Inferred from mutant phenotype
21880015 MGI
acts upstream of or within negative regulation of mitochondrial RNA catabolic process IGI
IGI: Inferred from genetic interaction
22045337 MGI
acts upstream of or within negative regulation of mitochondrial RNA catabolic process IMP
IMP: Inferred from mutant phenotype
21880015 MGI
acts upstream of or within regulation of mitochondrial translation IMP
IMP: Inferred from mutant phenotype
22045337 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12071956 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
14651853 MGI
located in nucleus IDA
IDA: Inferred from direct assay
12071956 MGI
part of ribonucleoprotein complex IDA
IDA: Inferred from direct assay
22045337 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

leucine-rich PPR motif-containing protein, mitochondrial

130 kDa leucine-rich protein

leucine rich protein LRP130

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-168519 STAT3-IN-36 Inhibitor / Unkown
HY-181098 FKA-9i / Unkown
HY-RS07804 LRPPRC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20563 Lrpprc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27072 Lrpprc Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lrpprc NCBI NCBI:10128