Rspo3 - R-spondin 3 Gene

Also Known as Thsd2; Cristin1; 2810459H04Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 72780

Summary

Enables Frizzled binding activity and heparin binding activity. Involved in blood vessel remodeling; positive regulation of non-canonical Wnt signaling pathway; and sprouting angiogenesis. Acts upstream of or within angiogenesis; branching involved in labyrinthine layer morphogenesis; and positive regulation of canonical Wnt signaling pathway. Located in extracellular region. Is expressed in several structures, including central nervous system; genitourinary system; heart; limb; and skeleton. Orthologous to human RSPO3 (R-spondin 3). [provided by Alliance of Genome Resources, Apr 2022]

Rspo3 Products (1)

mRNA Protein Name
NM_028351.3 NP_082627.3 R-spondin-3 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables frizzled binding IPI
IPI: Inferred from physical interaction
16543246 MGI
enables heparin binding IDA
IDA: Inferred from direct assay
16543246 MGI
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
16543246 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within angiogenesis IMP
IMP: Inferred from mutant phenotype
18842812 MGI
involved in blood vessel remodeling IMP
IMP: Inferred from mutant phenotype
26766444 MGI
acts upstream of or within branching involved in labyrinthine layer morphogenesis IMP
IMP: Inferred from mutant phenotype
16963017 MGI
acts upstream of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
18842812 MGI
acts upstream of or within positive regulation of canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
16543246 MGI
acts upstream of or within positive regulation of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
18842812 MGI
involved in positive regulation of non-canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
26766444 MGI
involved in sprouting angiogenesis IMP
IMP: Inferred from mutant phenotype
26766444 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular region IDA
IDA: Inferred from direct assay
16543246 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

R-spondin-3

  • R-spondin 3 homolog

  • cabriolet

  • cristin 1

  • cysteine-rich and single thrombospondin domain-containing protein 1

  • nucleopondin

  • roof plate-specific spondin-3

  • thrombospondin, type I, domain 2

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99401 Rosmantuzumab Inhibitor 99.29% Phase 1

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12307 RSPO3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17424 Rspo3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23879 Rspo3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rspo3 NCBI NCBI:84870