Appl1 - adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 Gene

Also Known as DIP13; 2900057D21Rik; 7330406P05Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 72993

Summary

Predicted to enable several functions, including beta-tubulin binding activity; phospholipid binding activity; and protein homodimerization activity. Involved in several processes, including cellular response to hepatocyte growth factor stimulus; positive regulation of cytokine production involved in inflammatory response; and regulation of vesicle-mediated transport. Located in cytoplasmic vesicle and ruffle. Is expressed in several structures, including liver; muscle tissue; spleen; stomach; and testis. Human ortholog(s) of this gene implicated in maturity-onset diabetes of the young type 14. Orthologous to human APPL1 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1). [provided by Alliance of Genome Resources, Apr 2022]

Appl1 Products (1)

mRNA Protein Name
NM_145221.3 NP_660256.1 DCC-interacting protein 13-alpha

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19661063 MGI
Biological Process GO Annotation Evidence References Source
involved in cellular response to hepatocyte growth factor stimulus IMP
IMP: Inferred from mutant phenotype
26445298 MGI
involved in negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis IMP
IMP: Inferred from mutant phenotype
25568335 MGI
involved in positive regulation of cytokine production involved in inflammatory response IMP
IMP: Inferred from mutant phenotype
25328665 MGI
involved in positive regulation of macropinocytosis IMP
IMP: Inferred from mutant phenotype
27219021 MGI
involved in regulation of fibroblast migration IMP
IMP: Inferred from mutant phenotype
26445298 MGI
involved in regulation of innate immune response IMP
IMP: Inferred from mutant phenotype
27219021 MGI
involved in regulation of toll-like receptor 4 signaling pathway IMP
IMP: Inferred from mutant phenotype
27219021 MGI
Cellular Component GO Annotation Evidence References Source
located in early endosome IDA
IDA: Inferred from direct assay
21849472 MGI
located in early phagosome IDA
IDA: Inferred from direct assay
25568335 MGI
located in endosome IDA
IDA: Inferred from direct assay
25568335 MGI
located in macropinosome IDA
IDA: Inferred from direct assay
27219021 MGI
located in ruffle IDA
IDA: Inferred from direct assay
25568335 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DCC-interacting protein 13-alpha

  • DIP13 alpha

  • adapter protein containing PH domain, PTB domain and leucine zipper motif 1

  • adaptor protein APPL like

  • dip13-alpha

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00867 APPL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20366 Appl1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26876 Appl1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Appl1 NCBI NCBI:26060