Muc16 - mucin 16 Gene

Also Known as Ca125; Gm1480; Gm21044; 1110008I14Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 73732

Summary

Acts upstream of or within negative regulation of epithelial cell proliferation; negative regulation of interleukin-6 production; and negative regulation of wound healing. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; mesothelium; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in ovarian Cancer. Orthologous to human MUC16 (Mucin 16, cell surface associated). [provided by Alliance of Genome Resources, Apr 2022]

Muc16 Products (1)

mRNA Protein Name
NM_001378248.1 NP_001365177.1 mucin-16 precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
24812549 MGI
acts upstream of or within negative regulation of interleukin-6 production IMP
IMP: Inferred from mutant phenotype
24812549 MGI
acts upstream of or within negative regulation of wound healing IMP
IMP: Inferred from mutant phenotype
24812549 MGI
Cellular Component GO Annotation Evidence References Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
18637025 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mucin-16

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P99539 Ubamatamab ≥99.0% Phase 2
HY-P99593 Sofituzumab vedotin 98.97% Phase 1

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08835 MUC16 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18071 Muc16 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24546 Muc16 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99237 Sofituzumab Inhibitor 99.90% Unkown
HY-P991166 Ubletamig Inhibitor / Unkown
HY-P992270 Anti-MUC16 Antibody (MMUC3333A) / Unkown
HY-P990830 Anti-MUC16 Antibody (VK8) Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Muc16 NCBI NCBI:94025