Dnm1l - dynamin 1-like Gene

Also Known as Dlp1; Drp1; Dnmlp1; python; 6330417M19Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 74006

Summary

This gene encodes a member of the Dynamin family. The encoded protein is localized to the cytoplasm and mitochondrial membrane, is involved in mitochondrial and peroxisomal division, and is essential for mitochondrial fission. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 2. [provided by RefSeq, Feb 2013]

Dnm1l Products (22)

mRNA	Protein	Name
NM_001025947.3	NP_001021118.1	dynamin-1-like protein isoform b
NM_001276340.2	NP_001263269.1	dynamin-1-like protein isoform c
NM_001276341.2	NP_001263270.1	dynamin-1-like protein isoform d
NM_001360007.2	NP_001346936.1	dynamin-1-like protein isoform e
NM_001360008.2	NP_001346937.1	dynamin-1-like protein isoform f
NM_001360009.2	NP_001346938.1	dynamin-1-like protein isoform g
NM_001360010.2	NP_001346939.1	dynamin-1-like protein isoform h
NM_001405252.1	NP_001392181.1	dynamin-1-like protein isoform d
NM_001405253.1	NP_001392182.1	dynamin-1-like protein isoform i
NM_001405254.1	NP_001392183.1	dynamin-1-like protein isoform j
NM_001405255.1	NP_001392184.1	dynamin-1-like protein isoform k
NM_001405256.1	NP_001392185.1	dynamin-1-like protein isoform l
NM_001405257.1	NP_001392186.1	dynamin-1-like protein isoform m
NM_001405258.1	NP_001392187.1	dynamin-1-like protein isoform n
NM_001405259.1	NP_001392188.1	dynamin-1-like protein isoform o
NM_001405260.1	NP_001392189.1	dynamin-1-like protein isoform p
NM_001405261.1	NP_001392190.1	dynamin-1-like protein isoform q
NM_001405262.1	NP_001392191.1	dynamin-1-like protein isoform r
NM_001405263.1	NP_001392192.1	dynamin-1-like protein isoform s
NM_001405264.1	NP_001392193.1	dynamin-1-like protein isoform t
NM_001405265.1	NP_001392194.1	dynamin-1-like protein isoform t
NM_152816.4	NP_690029.2	dynamin-1-like protein isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22639965	MGI
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	20585624	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within calcium ion transport	IMP IMP: Inferred from mutant phenotype	28063983	MGI
involved in heart contraction	IMP IMP: Inferred from mutant phenotype	20585624	MGI
acts upstream of or within mitochondrial fission	IMP IMP: Inferred from mutant phenotype	20038678	MGI
involved in mitochondrial fission	IMP IMP: Inferred from mutant phenotype	22265414	MGI
acts upstream of or within mitochondrion organization	IMP IMP: Inferred from mutant phenotype	28063983	MGI
acts upstream of or within mitocytosis	IMP IMP: Inferred from mutant phenotype	34048705	MGI
involved in peroxisome fission	IMP IMP: Inferred from mutant phenotype	29853636	MGI
acts upstream of or within protein localization to mitochondrion	IMP IMP: Inferred from mutant phenotype	24515348	MGI
involved in regulation of ATP metabolic process	IMP IMP: Inferred from mutant phenotype	20585624	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	28063983	MGI
involved in regulation of mitochondrion organization	IMP IMP: Inferred from mutant phenotype	20585624	MGI
involved in regulation of peroxisome organization	IMP IMP: Inferred from mutant phenotype	20585624	MGI
acts upstream of or within regulation of ubiquitin protein ligase activity	IMP IMP: Inferred from mutant phenotype	28063983	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in brush border	IDA IDA: Inferred from direct assay	22114352	MGI
located in cytosol	IDA IDA: Inferred from direct assay	30059978	MGI
located in cytosol	IMP IMP: Inferred from mutant phenotype	23283981	MGI
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	21149567	MGI
located in mitochondrion	IDA IDA: Inferred from direct assay	24515348	MGI
located in mitochondrion	IMP IMP: Inferred from mutant phenotype	23283981	MGI
located in peroxisome	IDA IDA: Inferred from direct assay	29853636	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
dynamin-1-like protein	dymple dynamin family member proline-rich carboxyl-terminal domain less dynamin-related protein 1

Dnm1l Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Dnm1l	Q8K1M6	Mief1	Mus musculus	Q8BGV8	Crosslink	30914652
Intra	Dnm1l	Q8K1M6	Mff	Mus musculus	Q6PCP5	Crosslink	30914652
Intra	Dnm1l	Q8K1M6	Lrrk2	Mus musculus	Q5S006	Anti Bait CoIP	22639965
Intra	Dnm1l	Q8K1M6	Atad3	Mus musculus	Q925I1	Anti Bait CoIP	30914652

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03904	DNM1L Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17698	Dnm1l Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24160	Dnm1l Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dnm1l	NCBI	NCBI:10059