VGF - VGF nerve growth factor inducible Gene

Also Known as SCG7; SgVII

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7425

About VGF

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:101,162,509-101,169,952 (from NCBI)

This gene has 2 transcripts (splice variants) and 72 orthologues. Biased expression in brain (RPKM 14.2) and fat (RPKM 1.5).

Summary

This gene is specifically expressed in a subpopulation of neuroendocrine cells, and is upregulated by nerve growth factor. The structural organization of this gene is similar to that of the rat gene, and both the translated and the untranslated regions show a high degree of sequence similarity to the rat gene. The encoded secretory protein also shares similarities with the secretogranin/chromogranin family, however, its exact function is not known. [provided by RefSeq, Jul 2008]

VGF Products (1)

mRNA Protein Name
NM_003378.4 NP_003369.2 neurosecretory protein VGF precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in response to cAMP IEP
IEP: Inferred from expression pattern
10381005 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
17440014 GOA
located in extracellular space IDA
IDA: Inferred from direct assay
15706611 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neurosecretory protein VGF

  • neuro-endocrine specific protein VGF

Related Diseases

Diseases Alias
Vaccinia
Pheochromocytoma

  • Pheochromocytoma, Susceptibility To

  • Phaeochromocytoma

  • Adrenal Gland Chromaffin Paraganglioma

  • Adrenal Gland Chromaffinoma

  • Adrenal Gland Paraganglioma

  • Adrenal Gland Pheochromocytoma

  • Chromaffin Paraganglioma Of The Adrenal Gland

  • Intraadrenal Paraganglioma

  • PCC

  • Chromaffin Cell Tumor

  • Medullary Chromaffinoma

  • Medullary Paraganglioma

  • Pheochromoblastoma

  • Pheochromocytomas

  • Chromaffin Cell Neoplasm

  • Pheochromocytoma, Malignant
Major Depressive Disorder

  • Seasonal Affective Disorder

  • Unipolar Depression

  • Depression

  • MDD

  • Depressive Disorder

  • Unipolar Depression, Susceptibility To

  • Major Depressive Disorder 1

  • Major Depressive Disorder, Response To Citalopram Therapy In

  • Major Depressive Disorder 2

  • Winter Depression

  • Single Major Depressive Episode

  • Sad

  • Clinical Depression

  • Major Depression

  • Depressive Syndrome

  • Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment

  • Seasonal Affective Disorder, Susceptibility To

  • Recurrent Major Depression

  • Affective Disorder, Seasonal

  • Depression In A Seasonal Pattern

  • Depression

  • Seasonal

  • Major Depressive Disorder With A Seasonal Pattern

  • Seasonal Depression

  • Seasonal Mood Disorder

  • Mental Depression

  • Recurrent Major Depressive Episodes
Spinocerebellar Ataxia 23

  • Spinocerebellar Ataxia Type 23

  • SCA23

  • Ataxia, Spinocerebellar, Type 23
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-16728 Rapastinel 99.78% Phase 3

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-107760 Decanoyl-RVKR-CMK Inhibitor 99.64% Unkown
HY-P1345A TLQP-21 TFA Agonist 99.90% Unkown
HY-16728B Rapastinel Trifluoroacetate 98.0% Unkown
HY-107760A Decanoyl-RVKR-CMK TFA Inhibitor 98.04% Unkown
HY-RS17940 Vgf Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-16728A Rapastinel acetate / Unkown
HY-P11092 TLQP-62 (mouse,rat) / Unkown
HY-P11130 LQEQ-19 (mouse, rat) Activator / Unkown
HY-P1345 TLQP-21 Agonist / Unkown
HY-RS15643 VGF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24411 Vgf Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta VGF VGNC VGNC:78767
Rattus norvegicus VGF RGD RGD:69399
Canis familiaris VGF VGNC VGNC:54090
Felis catus VGF VGNC VGNC:107829
Bos taurus VGF VGNC VGNC:36790
Mus musculus VGF MGD MGI:1343180
Others VGF NCBI