Sost - sclerostin Gene

Also Known as 5430411E23Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 74499

Summary

Predicted to enable BMP binding activity. Acts upstream of or within negative regulation of ossification; negative regulation of signal transduction; and ossification. Predicted to be located in Golgi apparatus. Predicted to be part of protein-containing complex. Predicted to be active in extracellular space. Is expressed in several structures, including arterial system; jaw; limb bud; nervous system; and skeleton. Used to study SOST-related sclerosing bone dysplasia and sclerosteosis 1. Human ortholog(s) of this gene implicated in SOST-related sclerosing bone dysplasia; autosomal dominant craniodiaphyseal dysplasia; sclerosteosis; and sclerosteosis 1. Orthologous to human SOST (sclerostin). [provided by Alliance of Genome Resources, Apr 2022]

Sost Products (1)

mRNA Protein Name
NM_024449.6 NP_077769.4 sclerostin precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17002572 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of BMP signaling pathway IDA
IDA: Inferred from direct assay
17002572 MGI
acts upstream of canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
19896444 MGI
acts upstream of or within negative regulation of BMP signaling pathway IDA
IDA: Inferred from direct assay
17002572 MGI
acts upstream of or within negative regulation of Wnt signaling pathway IDA
IDA: Inferred from direct assay
17002572 MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
19896444 MGI
acts upstream of or within negative regulation of ossification IMP
IMP: Inferred from mutant phenotype
23918385 MGI
acts upstream of or within ossification IDA
IDA: Inferred from direct assay
14633986 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sclerostin

Recombinant Sost Proteins

Cat. No. Product Name Accession Purity
HY-P70717 SOST Protein, Mouse (HEK293, His) AAK13455.1 (Q24-Y211) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-101149 YKL-05-093 Inhibitor / Unkown
HY-RS13578 SOST Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16993 Sost Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23436 Sost Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992113 Evabosmig Activator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sost NCBI NCBI:50964