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Pik3cb - phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta Gene

Also Known as p110beta; 1110001J02Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 74769

About Pik3cb

Chromosome 9: 98,918,707-99,022,674 reverse strand.GRCm39:CM001002.3

This gene has 3 transcripts (splice variants), 214 orthologues, 9 paralogues and is associated with 48 phenotypes. Ubiquitous expression in placenta adult (RPKM 11.2), subcutaneous fat pad adult (RPKM 5.) and 28 other tissues.

Summary

Enables 1-phosphatidylinositol-3-kinase activity and Insulin Receptor substrate binding activity. Involved in several processes, including phosphatidylinositol 3-kinase signaling; regulation of intracellular signal transduction; and response to ischemia. Acts upstream of or within several processes, including angiogenesis involved in wound healing; embryonic cleavage; and homophilic cell adhesion via plasma membrane adhesion molecules. Located in nucleus. Is expressed in several structures, including early embryo; genitourinary system; liver; respiratory system; and spleen. Human ortholog(s) of this gene implicated in glioblastoma; prostate adenocarcinoma; prostate cancer; and type 2 diabetes mellitus. Orthologous to human PIK3CB (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta). [provided by Alliance of Genome Resources, Apr 2022]

Pik3cb Products (1)

mRNA	Protein	Name
NM_029094.3	NP_083370.2	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 1-phosphatidylinositol-3-kinase activity	IMP IMP: Inferred from mutant phenotype	15834429	MGI
enables insulin receptor substrate binding	IPI IPI: Inferred from physical interaction	16625210	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15102471	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within angiogenesis involved in wound healing	IMP IMP: Inferred from mutant phenotype	25139353	MGI
acts upstream of or within embryonic cleavage	IMP IMP: Inferred from mutant phenotype	11919689	MGI
acts upstream of or within endothelial cell proliferation	IMP IMP: Inferred from mutant phenotype	25139353	MGI
acts upstream of or within homophilic cell adhesion via plasma membrane adhesion molecules	IMP IMP: Inferred from mutant phenotype	15834429	MGI
acts upstream of or within intracellular calcium ion homeostasis	IMP IMP: Inferred from mutant phenotype	15834429	MGI
involved in negative regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	30496354	MGI
involved in negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	30496354	MGI
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	30496354	MGI
involved in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IGI IGI: Inferred from genetic interaction	18558630	MGI
involved in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	30496354	MGI
acts upstream of or within platelet activation	IMP IMP: Inferred from mutant phenotype	15834429	MGI
involved in positive regulation of Rac protein signal transduction	IGI IGI: Inferred from genetic interaction	18558630	MGI
involved in positive regulation of endothelial cell migration	IGI IGI: Inferred from genetic interaction	18558630	MGI
acts upstream of or within regulation of cell-matrix adhesion	IMP IMP: Inferred from mutant phenotype	15834429	MGI
involved in response to ischemia	IMP IMP: Inferred from mutant phenotype	30496354	MGI
involved in sphingosine-1-phosphate receptor signaling pathway	IGI IGI: Inferred from genetic interaction	18558630	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	30496354	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pik3cb Protein Structure

PI3K_p85B

PI3K_rbd

C2_PI3K_class_I_beta_delta

PI3Ka_I

PI3Kc_IA_beta

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800
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1064 a.a.

Protein Preferred Names	Protein Names
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	PI3-kinase subunit beta PI3K-beta PI3Kbeta phosphatidylinositol 3-kinase, catalytic, beta polypeptide phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta ptdIns-3-kinase subunit beta ptdIns-3-kinase subunit p110-beta serine/threonine protein kinase PIK3CB

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-126077	MTI-31	Inhibitor	99.92%	Phase 1

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10526	PIK3CB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10527	Pik3cb Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10528	PIK3CB Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pik3cb	NCBI	NCBI:5291