PIK3CB
p110β, the catalytic subunit encoded by PIK3CB, partners with p85-family regulatory subunits and is unique among class IA PI3Ks in responding to both receptor tyrosine kinases and G protein-coupled receptors, through its Ras-binding domain and interactions with Gβγ subunits. It generates PIP3 to activate AKT signaling and is the dominant isoform in PTEN-deficient tumors, where it sustains survival signaling after loss of the lipid phosphatase. p110β also contributes to insulin action, platelet function and neutrophil chemotaxis, features underpinning ongoing development of p110β-selective inhibitors for cancer and inflammatory indications. Compared with p110α, p110β activity is less dependent on input from oncogenic Ras, a distinction that shapes isoform-selective drug design.
-
PIK3CB Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
