Manf - mesencephalic astrocyte-derived neurotrophic factor Gene

Also Known as Armet; D18Mgi17; 3230402M22Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 74840

Summary

Predicted to enable sulfatide binding activity. Acts upstream of or within vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure. Predicted to be located in endoplasmic reticulum lumen and perinuclear region of cytoplasm. Predicted to be active in endoplasmic reticulum and extracellular space. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in Parkinsonism; breast cancer; carcinoma (multiple); and pancreatic Cancer. Orthologous to human MANF (mesencephalic astrocyte derived neurotrophic factor). [provided by Alliance of Genome Resources, Apr 2022]

Manf Products (1)

mRNA Protein Name
NM_029103.4 NP_083379.2 mesencephalic astrocyte-derived neurotrophic factor precursor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure IDA
IDA: Inferred from direct assay
18718866 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mesencephalic astrocyte-derived neurotrophic factor

  • arginine-rich protein

  • arginine-rich, mutated in early stage tumors

Recombinant Manf Proteins

Cat. No. Product Name Accession Purity
HY-P77296 ARMET/MANF Protein, Mouse (HEK293, His) Q9CXI5/NP_083379.2 (L22-L179) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08017 MANF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18040 Manf Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24514 Manf Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Manf NCBI NCBI:7873