Mettl4 - methyltransferase like 4 Gene

Also Known as HsT661; 2410198H06Rik; A730091E08Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 76781

Summary

Enables site-specific DNA-methyltransferase (adenine-specific) activity. Involved in DNA methylation on adenine and regulation of chromatin organization. Predicted to be located in mitochondrial matrix. Predicted to be active in cytosol and nucleus. Orthologous to human METTL4 (methyltransferase 4, N6-adenosine). [provided by Alliance of Genome Resources, Apr 2022]

Mettl4 Products (5)

mRNA Protein Name
NM_001357135.1 NP_001344064.1 N(6)-adenine-specific methyltransferase METTL4 isoform 1
NM_001357136.1 NP_001344065.1 N(6)-adenine-specific methyltransferase METTL4 isoform 1
NM_001357137.1 NP_001344066.1 N(6)-adenine-specific methyltransferase METTL4 isoform 2
NM_001357138.1 NP_001344067.1 N(6)-adenine-specific methyltransferase METTL4 isoform 2
NM_176917.5 NP_795891.2 N(6)-adenine-specific methyltransferase METTL4 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables site-specific DNA-methyltransferase (adenine-specific) activity IDA
IDA: Inferred from direct assay
30982744 MGI
Biological Process GO Annotation Evidence References Source
involved in negative regulation of gene expression, epigenetic IDA
IDA: Inferred from direct assay
30982744 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

N(6)-adenine-specific methyltransferase METTL4

  • N(6)-adenine-specific DNA methyltransferase METTL4

  • methyltransferase-like protein 4

  • snRNA (2'-O-methyladenosine-N(6)-)-methyltransferase METTL4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08365 METTL4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21883 Mettl4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28400 Mettl4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mettl4 NCBI NCBI:64863