Lrg1 - leucine-rich alpha-2-glycoprotein 1 Gene

Also Known as Lrg; Lrhg; 1300008B03Rik; 2310031E04Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 76905

Summary

Enables transforming growth factor beta receptor binding activity. Acts upstream of or within several processes, including brown fat cell differentiation; positive regulation of endothelial cell proliferation; and positive regulation of transforming growth factor beta receptor signaling pathway. Located in extracellular space. Is expressed in pancreas mesenchyme. Orthologous to human LRG1 (leucine rich alpha-2-glycoprotein 1). [provided by Alliance of Genome Resources, Apr 2022]

Lrg1 Products (2)

mRNA Protein Name
NM_029796.2 NP_084072.1 leucine-rich alpha-2-glycoprotein precursor
NM_029796.2 NP_084072.1 leucine-rich alpha-2-glycoprotein precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables transforming growth factor beta receptor binding IPI
IPI: Inferred from physical interaction
23868260 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within brown fat cell differentiation IDA
IDA: Inferred from direct assay
18492766 MGI
acts upstream of or within positive regulation of angiogenesis IDA
IDA: Inferred from direct assay
23868260 MGI
acts upstream of or within positive regulation of angiogenesis IGI
IGI: Inferred from genetic interaction
23868260 MGI
acts upstream of or within positive regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
23868260 MGI
acts upstream of or within positive regulation of endothelial cell proliferation IMP
IMP: Inferred from mutant phenotype
23868260 MGI
acts upstream of or within positive regulation of transforming growth factor beta receptor signaling pathway IGI
IGI: Inferred from genetic interaction
23868260 MGI
acts upstream of or within response to bacterium IEP
IEP: Inferred from expression pattern
23012479 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
23868260 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

leucine-rich alpha-2-glycoprotein

Lrg1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Lrg1 Q91XL1 Klk10 Mus musculus Q99M20
Anti Bait CoIP
38707515
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Lrg1 Proteins

Cat. No. Product Name Accession Purity
HY-P77987 LRG1 Protein, Mouse (HEK293, His) Q91XL1 (L33-L342) ≥ 95%, as determined by reducing SDS-PAGE or Bis-Tris PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P10899 ETTAC-2 Inhibitor 99.94% Unkown
HY-RS16806 Lrg1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07784 LRG1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23246 Lrg1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lrg1 NCBI NCBI:116844
Macaca fascicularis Lrg1 NCBI NCBI:102118680
Rattus norvegicus Lrg1 NCBI NCBI:367455