Nol3 - nucleolar protein 3 (apoptosis repressor with CARD domain) Gene

Also Known as ARC; MYC; NOP; Nop30; B430311C09Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 78688

Summary

Enables death effector domain binding activity and death receptor binding activity. Involved in several processes, including cardiac muscle cell apoptotic process; negative regulation of cell death; and regulation of signal transduction. Acts upstream of or within regulation of gene expression; response to hypoxia; and response to injury involved in regulation of muscle adaptation. Located in mitochondrion and sarcoplasm. Is expressed in adrenal gland; brain; lung; metanephros; and musculature. Orthologous to human NOL3 (nucleolar protein 3). [provided by Alliance of Genome Resources, Apr 2022]

Nol3 Products (1)

mRNA Protein Name
NM_030152.4 NP_084428.1 nucleolar protein 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables death effector domain binding IPI
IPI: Inferred from physical interaction
15383280 MGI
enables death receptor binding IPI
IPI: Inferred from physical interaction
24440909 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15383280 MGI
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
15383280 MGI
Biological Process GO Annotation Evidence References Source
involved in blood vessel remodeling IMP
IMP: Inferred from mutant phenotype
22082675 MGI
involved in cardiac muscle cell apoptotic process IMP
IMP: Inferred from mutant phenotype
16505176 MGI
involved in intrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
24312627 MGI
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
22082675 MGI
involved in negative regulation of cardiac muscle cell apoptotic process IMP
IMP: Inferred from mutant phenotype
16505176 MGI
involved in negative regulation of mitochondrial membrane permeability involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
24312627 MGI
involved in negative regulation of muscle atrophy IMP
IMP: Inferred from mutant phenotype
24312627 MGI
involved in negative regulation of programmed necrotic cell death IMP
IMP: Inferred from mutant phenotype
24440909 MGI
involved in negative regulation of striated muscle cell apoptotic process IMP
IMP: Inferred from mutant phenotype
24312627 MGI
involved in negative regulation of tumor necrosis factor-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
24440909 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
18782777 MGI
involved in regulation of non-canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
24440909 MGI
acts upstream of or within response to hypoxia IMP
IMP: Inferred from mutant phenotype
18782777 MGI
acts upstream of or within response to injury involved in regulation of muscle adaptation IMP
IMP: Inferred from mutant phenotype
18782777 MGI
involved in response to ischemia IMP
IMP: Inferred from mutant phenotype
16505176 MGI
Cellular Component GO Annotation Evidence References Source
located in mitochondrion IDA
IDA: Inferred from direct assay
14645204 MGI
located in sarcoplasm IDA
IDA: Inferred from direct assay
14645204 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nucleolar protein 3

  • apoptosis repressor with CARD

Nol3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Nol3 Q9D1X0 Tra2a Mus musculus Q6PFR5
Pull Down
16249178
Intra
Nol3 Q9D1X0 Tra2a Mus musculus Q6PFR5
Y2H
16249178
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09414 NOL3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18487 Nol3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24969 Nol3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nol3 NCBI NCBI:8996