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MAPKAP1 - MAPK associated protein 1 Gene

Also Known as MIP1; SIN1; JC310; SIN1b; SIN1g

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 79109

About MAPKAP1

Cytogenetic location: 9q33.3 Genomic coordinates (GRCh38): 9:125,437,394-125,707,208 (from NCBI)

This gene has 20 transcripts (splice variants) and 207 orthologues. Ubiquitous expression in thyroid (RPKM 18.8), testis (RPKM 17.4) and 25 other tissues.

Summary

This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been described. Alternate polyadenylation sites as well as alternate 3' UTRs have been identified for transcripts of this gene. [provided by RefSeq, Jul 2008]

MAPKAP1 Products (6)

mRNA	Protein	Name
NM_001006617.3	NP_001006618.1	target of rapamycin complex 2 subunit MAPKAP1 isoform 1
NM_001006618.2	NP_001006619.1	target of rapamycin complex 2 subunit MAPKAP1 isoform 5
NM_001006619.2	NP_001006620.1	target of rapamycin complex 2 subunit MAPKAP1 isoform 3
NM_001006620.2	NP_001006621.1	target of rapamycin complex 2 subunit MAPKAP1 isoform 4
NM_001006621.2	NP_001006622.1	target of rapamycin complex 2 subunit MAPKAP1 isoform 4
NM_024117.4	NP_077022.1	target of rapamycin complex 2 subunit MAPKAP1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	29567957	GOA
enables phosphatidic acid binding	IDA IDA: Inferred from direct assay	17303383	GOA
enables phosphatidylinositol-3,4,5-trisphosphate binding	IDA IDA: Inferred from direct assay	17303383	GOA
enables phosphatidylinositol-3,4-bisphosphate binding	IDA IDA: Inferred from direct assay	17303383	GOA
enables phosphatidylinositol-3,5-bisphosphate binding	IDA IDA: Inferred from direct assay	17303383	GOA
enables phosphatidylinositol-4,5-bisphosphate binding	IDA IDA: Inferred from direct assay	17303383	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	24365180	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	21177249	GOA
enables small GTPase binding	IDA IDA: Inferred from direct assay	17303383	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of Ras protein signal transduction	IMP IMP: Inferred from mutant phenotype	17303383	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	17303383	GOA
part of TORC2 complex	IPI IPI: Inferred from physical interaction	17461779	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	17303383	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAPKAP1 Protein Structure

SIN1

0
100
200
300
400
522 a.a.

Protein Preferred Names	Protein Names
target of rapamycin complex 2 subunit MAPKAP1	MEKK2-interacting protein 1

Related Diseases

Diseases	Alias
Short Syndrome	Short Stature, Hyperextensibility, Hernia, Ocular Depression, Rieger Anomaly, And Teething Delay Aarskog-Ose-Pande Syndrome Lipodystrophy, Partial, With Rieger Anomaly And Short Stature Lipodystrophy-Rieger Anomaly-Diabetes Syndrome Rieger Anomaly-Partial Lipodystrophy Syndrome Partial Lipodystrophy With Rieger Anomaly And Short Stature Short Stature, Hyperextensibility, Hernia, Ocular Depression, Rieger Anomaly And Teething Delay Growth Retardation-Rieger Anomaly Short Stature-Hyperextensibility-Rieger Anomaly-Teething Delay SHORTS
Dravet Syndrome	Severe Myoclonic Epilepsy Of Infancy Severe Myoclonic Epilepsy In Infancy Smei Epileptic Encephalopathy, Early Infantile, 6 DRVT Developmental And Epileptic Encephalopathy 6a Dee6a Eiee6 Developmental And Epileptic Encephalopathy, 6 Dee6 Developmental And Epileptic Encephalopathy 6 Early Infantile Epileptic Encephalopathy 6 Myoclonic Epilepsy, Severe, Of Infancy Sme Severe Myoclonus Epilepsy Of Infancy Borderline Smei Smeb Smeb-M Smeb-O Smeb-Sw Smei-Borderland Smei-Borderland More Than One Feature Smei-Borderland-Myoclonic Seizures Smei-Borderland-Spike Wave Intractable Childhood Epilepsy With Generalized Tonic-Clonic Seizures ICEGTC Infantile Severe Myoclonic Epilepsy Epilepsy, Intractable Childhood, With Generalized Tonic-Clonic Seizures
Bardet-Biedl Syndrome	Bbs Biedl-Bardet Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-176166	PD-M6		98.17%	Unkown
HY-N1190	DL-Syringaresinol	Inhibitor	96%	Unkown
HY-RS08130	MAPKAP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22009	Mapkap1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28527	Mapkap1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MAPKAP1	MGD	MGI:2444554
Felis catus	MAPKAP1	VGNC	VGNC:63382
Bos taurus	MAPKAP1	VGNC	VGNC:31228
Rattus norvegicus	MAPKAP1	RGD	RGD:1305363
Macaca mulatta	MAPKAP1	VGNC	VGNC:74531
Canis familiaris	MAPKAP1	VGNC	VGNC:43005
Others	MAPKAP1	NCBI