Apex1 - apurinic/apyrimidinic endodeoxyribonuclease 1 Gene

Also Known as APE; Apex; REF-1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 79116

Summary

Enables NF-kappaB binding activity and endoribonuclease activity. Involved in several processes, including cellular response to organonitrogen compound; negative regulation of smooth muscle cell migration; and positive regulation of G1/S transition of mitotic cell cycle. Located in mitochondrion and nucleus. Part of transcription regulator complex. Biomarker of brain ischemia; lung disease; status epilepticus; and visual epilepsy. Human ortholog(s) of this gene implicated in breast cancer; female reproductive organ Cancer (multiple); spina bifida; and urinary bladder Cancer. Orthologous to human APEX1 (apurinic/apyrimidinic endodeoxyribonuclease 1). [provided by Alliance of Genome Resources, Apr 2022]

Apex1 Products (1)

mRNA Protein Name
NM_024148.1 NP_077062.1 DNA-(apurinic or apyrimidinic site) endonuclease

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables NF-kappaB binding IDA
IDA: Inferred from direct assay
17602955 RGD
enables RNA endonuclease activity IDA
IDA: Inferred from direct assay
19401441 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
17280489 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
15084519 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to Thyroid stimulating hormone IEP
IEP: Inferred from expression pattern
12173070 RGD
involved in cellular response to cAMP IEP
IEP: Inferred from expression pattern
12173070 RGD
involved in cellular response to hydrogen peroxide IDA
IDA: Inferred from direct assay
12884291 RGD
involved in cellular response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
12173070 RGD
involved in negative regulation of smooth muscle cell migration IMP
IMP: Inferred from mutant phenotype
19038866 RGD
involved in positive regulation of G1/S transition of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
12730053 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
17264098 RGD
Cellular Component GO Annotation Evidence References Source
part of transcription regulator complex IDA
IDA: Inferred from direct assay
15084519 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA-(apurinic or apyrimidinic site) endonuclease

  • AP endonuclease 1

  • APEN

  • APEX nuclease (multifunctional DNA repair enzyme) 1

  • APEX nuclease 1

  • DNA-(apurinic or apyrimidinic site) lyase

  • apurinic/apyrimidinic endonuclease 1

  • redox factor-1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00815 APEX1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21480 Apex1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27998 Apex1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Apex1 NCBI NCBI:328