Arf6 - ADP-ribosylation factor 6 Gene

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 79121

Summary

Predicted to enable guanyl ribonucleotide binding activity; protein N-terminus binding activity; and thioesterase binding activity. Involved in several processes, including cellular response to nerve growth factor stimulus; maintenance of postsynaptic density structure; and negative regulation of dendrite development. Located in endosome; plasma membrane; and ruffle. Is active in glutamatergic synapse. Orthologous to human ARF6 (ADP ribosylation factor 6). [provided by Alliance of Genome Resources, Apr 2022]

Arf6 Products (1)

mRNA	Protein	Name
NM_024152.2	NP_077066.1	ADP-ribosylation factor 6

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to nerve growth factor stimulus	IDA IDA: Inferred from direct assay	26446845	RGD
involved in endocytic recycling	IDA IDA: Inferred from direct assay	26446845	RGD
involved in maintenance of postsynaptic density structure	IDA IDA: Inferred from direct assay	16672654	RGD
involved in maintenance of postsynaptic density structure	IMP IMP: Inferred from mutant phenotype	16672654	RGD
involved in negative regulation of dendrite development	IMP IMP: Inferred from mutant phenotype	12032543	RGD
involved in regulation of dendritic spine development	IMP IMP: Inferred from mutant phenotype	16672654	RGD
involved in regulation of presynapse assembly	IDA IDA: Inferred from direct assay	16672654	RGD
involved in regulation of presynapse assembly	IMP IMP: Inferred from mutant phenotype	16672654	RGD
involved in synaptic vesicle endocytosis	IDA IDA: Inferred from direct assay	26731518	RGD
involved in synaptic vesicle endocytosis	IMP IMP: Inferred from mutant phenotype	26731518	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in early endosome	IDA IDA: Inferred from direct assay	18353411	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	16672654	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	16672654	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	26731518	RGD
is active in presynapse	IDA IDA: Inferred from direct assay	26731518	RGD
located in recycling endosome	IDA IDA: Inferred from direct assay	18353411	RGD
located in ruffle	IDA IDA: Inferred from direct assay	11950936	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
ADP-ribosylation factor 6

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112473	Grassofermata	Inhibitor	99.10%	Unkown
HY-139950	Rasarfin	Inhibitor	99.57%	Unkown
HY-RS00898	ARF6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-P10178	Myristoylated ARF6 (2-13)	Inhibitor	/	Unkown
HY-P10179	ARF6 (2-13)		/	Unkown
HY-RS18229	Arf6 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24708	Arf6 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Arf6	NCBI	NCBI:382