Cfi - complement factor I Gene

Also Known as FI

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 79126

Summary

Predicted to enable metal ion binding activity; scavenger receptor activity; and serine-type endopeptidase activity. Involved in cellular response to interleukin-6. Located in extracellular space and nucleus. Human ortholog(s) of this gene implicated in Kuhnt-Junius degeneration; age related macular degeneration 13; atypical hemolytic-uremic syndrome; complement factor I deficiency; and macular degeneration. Orthologous to human CFI (complement factor I). [provided by Alliance of Genome Resources, Apr 2022]

Cfi Products (1)

mRNA Protein Name
NM_024157.1 NP_077071.1 complement factor I precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in cellular response to interleukin-6 IEP
IEP: Inferred from expression pattern
11530941 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
11530941 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

complement factor I

  • C3B/C4B inactivator

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-12300 Ocifisertib 99.78% Phase 2
HY-101340A Luvixasertib hydrochloride Inhibitor 99.63% Phase 2
HY-12300B Ocifisertib fumarate Inhibitor 98.69% Phase 2
HY-101340 Luvixasertib Inhibitor 99.9600% Phase 1

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-132135 (1E)-CFI-400437 dihydrochloride Inhibitor 98.08% Unkown
HY-12300A Ocifisertib hydrochloride / Unkown
HY-116190 CFI-401870 Inhibitor / Unkown
HY-120032 CFI-401980 Inhibitor / Unkown
HY-120279A CFI-400437 Inhibitor / Unkown
HY-123675 CFI-400936 Inhibitor / Unkown
HY-RS02567 CFI Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20677 Cfi Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27188 Cfi Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cfi NCBI NCBI:3426