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Cat. No.: HY-123675

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CFI-400936

CFI-400936 is a potent TTK inhibitor with an IC₅₀ of 3.6 nM. CFI-400936 has antitumor activity.

For research use only. We do not sell to patients.

CAS No.: 1338793-07-9
Formula: C₂₅H₂₇N₅O₃S
Molecular Weight:477.58

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

CFI-400936 Chemical Structure

CAS No.: 1338793-07-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

CFI-400936 is a potent TTK inhibitor with an IC₅₀ of 3.6 nM. CFI-400936 has antitumor activity^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	GI₅₀	0.16 μM Compound: 72, CFI-400936	Growth inhibition of human A549 cells after 5 days by SRB assay Growth inhibition of human A549 cells after 5 days by SRB assay	[PMID: 25043312]
HCT-116	EC₅₀	0.52 μM Compound: 72, CFI-400936	Inhibition of TTK in human HCT116 cells assessed as phosphorylation of histone H3 at Ser10 residue after 4 hrs by immunoassay Inhibition of TTK in human HCT116 cells assessed as phosphorylation of histone H3 at Ser10 residue after 4 hrs by immunoassay	[PMID: 25043312]
HCT-116	GI₅₀	0.1 μM Compound: 72, CFI-400936	Growth inhibition of human HCT116 cells after 5 days by SRB assay Growth inhibition of human HCT116 cells after 5 days by SRB assay	[PMID: 25043312]
MDA-MB-468	GI₅₀	0.66 μM Compound: 72, CFI-400936	Growth inhibition of human MDA-MB-468 cells after 5 days by SRB assay Growth inhibition of human MDA-MB-468 cells after 5 days by SRB assay	[PMID: 25043312]

Chemical Information

CAS No. 1338793-07-9
Molecular Weight 477.58
Formula C₂₅H₂₇N₅O₃S
SMILES

O=C(C(N(C)C)C1=C(CC)C=CC=C1)NC2=CC3=C(NN=C3C4=CC(S(=O)(N)=O)=CC=C4)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Laufer R, et al. Discovery of inhibitors of the mitotic kinase TTK based on N-(3-(3-sulfamoylphenyl)-1H-indazol-5-yl)-acetamides and carboxamides. Bioorg Med Chem. 2014 Sep 1;22(17):4968-97. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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