DEK - DEK proto-oncogene Gene

Also Known as D6S231E

Species: Homo sapiens (human)

Gene Type: protein coding
Gene ID: 7913

Summary

This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

DEK Products (1)

mRNA Protein Name
XM_054356378.1 XP_054212353.1 protein DEK isoform X2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables histone binding IDA
IDA: Inferred from direct assay
12140263 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
22113938 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of transcription by RNA polymerase III IDA
IDA: Inferred from direct assay
16603771 GOA
acts upstream of or within regulation of double-strand break repair IMP
IMP: Inferred from mutant phenotype
21653549 GOA
Cellular Component GO Annotation Evidence References Source
part of B-WICH complex IDA
IDA: Inferred from direct assay
16603771 GOA
located in nucleus IDA
IDA: Inferred from direct assay
21653549 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein DEK

  • DEK oncogene (DNA binding)

DEK Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DEK P35659 GPATCH11 Homo sapiens Q8N954-2
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

DEK Antibodies

Cat. No. Product Name Application Reactivity
HY-P81465 DEK Antibody (YA1210) IHC-P Human
HY-P81465A DEK Antibody (YA1210)(PBS only) IHC-P Human

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16386 DEK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20679 Dek Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27190 Dek Rat Pre-designed siRNA Set A Pre-designed Set / Unkown