Aspa - aspartoacylase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 79251

Summary

Enables identical protein binding activity. Involved in central nervous system myelination and positive regulation of oligodendrocyte differentiation. Located in cytoplasm and nucleus. Used to study Canavan disease. Human ortholog(s) of this gene implicated in Canavan disease. Orthologous to human ASPA (aspartoacylase). [provided by Alliance of Genome Resources, Apr 2022]

Aspa Products (1)

mRNA Protein Name
NM_024399.2 NP_077375.2 aspartoacylase

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
17194761 RGD
Biological Process GO Annotation Evidence References Source
involved in central nervous system myelination IEP
IEP: Inferred from expression pattern
12524181 RGD
involved in positive regulation of oligodendrocyte differentiation IMP
IMP: Inferred from mutant phenotype
16634055 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

aspartoacylase

  • ACY-2

  • aminoacylase-2

Aspa Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Aspa Q9R1T5 Aspa Rattus norvegicus Q9R1T5
GMS
17194761
Intra
Aspa Q9R1T5 Aspa Rattus norvegicus Q9R1T5
X-Ray Diffraction
17194761
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-148089 Eplontersen Inhibitor 98.70% Unkown
HY-B1680 Lithium citrate 98.0% Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-132579 Tominersen 96.32% Phase 3

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N6246 Asperulosidic Acid Inhibitor 99.63% Unkown
HY-RS01099 ASPA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17737 Aspa Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24202 Aspa Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Aspa NCBI NCBI:443