SAP130 - Sin3A associated protein 130 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79595

About SAP130

Cytogenetic location: 2q14.3 Genomic coordinates (GRCh38): 2:127,941,222-128,028,059 (from NCBI)

This gene has 6 transcripts (splice variants) and 228 orthologues. Broad expression in testis (RPKM 33.8), bone marrow (RPKM 7.4) and 24 other tissues.

Summary

SAP130 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003 [PubMed 12724404]).[supplied by OMIM, Mar 2008]

SAP130 Products (7)

mRNA Protein Name
NM_001145928.2 NP_001139400.1 histone deacetylase complex subunit SAP130 isoform a
NM_001330299.2 NP_001317228.1 histone deacetylase complex subunit SAP130 isoform c
NM_001330300.2 NP_001317229.1 histone deacetylase complex subunit SAP130 isoform d
NM_001330301.2 NP_001317230.1 histone deacetylase complex subunit SAP130 isoform e
NM_001330302.2 NP_001317231.1 histone deacetylase complex subunit SAP130 isoform f
NM_001330303.2 NP_001317232.1 histone deacetylase complex subunit SAP130 isoform g
NM_024545.4 NP_078821.2 histone deacetylase complex subunit SAP130 isoform b

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
22783022 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

histone deacetylase complex subunit SAP130

  • 130 kDa Sin3-associated polypeptide

Related Diseases

Diseases Alias
Pleuropneumonia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12437 SAP130 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12762 SF3B3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18715 Sap130 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20489 Sf3b3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25202 Sap130 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris SAP130 VGNC VGNC:45858
Mus musculus SAP130 MGD MGI:1919782
Bos taurus SAP130 VGNC VGNC:34280
Macaca mulatta SAP130 VGNC VGNC:77127
Felis catus SAP130 VGNC VGNC:64868
Rattus norvegicus SAP130 RGD RGD:1311657
Others SAP130 NCBI