C11orf80 - chromosome 11 open reading frame 80 Gene

Homo sapiens

Also known as HYDM4; TOP6BL; TOPOVIBL

Gene ID: 79703 | Gene type: protein coding

About C11orf80

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:66,744,736-66,843,516 (from NCBI)

This gene has 19 transcripts (splice variants), 128 orthologues and is associated with 2 phenotypes. Broad expression in skin (RPKM 13.7), testis (RPKM 6.8) and 22 other tissues.

Summary

Predicted to be involved in meiotic DNA double-strand break formation and reciprocal meiotic recombination. Predicted to be located in chromosome. Implicated in gestational trophoblastic neoplasm. [provided by Alliance of Genome Resources, Apr 2022]

C11orf80 Products(2)

mRNA	Protein	Name
NM_001302084.2	NP_001289013.1	type 2 DNA topoisomerase 6 subunit B-like isoform b
NM_024650.3	NP_078926.3	type 2 DNA topoisomerase 6 subunit B-like isoform a

C11orf80 Protein Structure

DUF4554

0
100
200
298 a.a.

Protein Preferred Names

Protein Names

type 2 DNA topoisomerase 6 subunit B-like

type 2 DNA topoisomerase VI subunit B-like

Related Diseases

Diseases

Alias

Hydatidiform Mole, Recurrent, 4

HYDM4

Hydatidiform Mole, Recurrent, 1

Hydatidiform Mole	Gestational Trophoblastic Disease
Complete Hydatidiform Mole	Hydm
HYDM1	Chm
Molar Pregnancy	Hydatidiform Mole, Complete
Hydatid Mole	Complete Molar Pregnancy
Mole, Hydatidiform, Recurrent, Type 1	Gestational Trophoblastic Neoplasms
Hydatidiform Mole, Recurrent, 2	Classical Hydatidiform Mole

Trophoblastic Neoplasm

Trophoblastic Tumor

Trophoblastic Neoplasms

Gestational Trophoblastic Neoplasm

Hydatidiform Mole	Molar Pregnancy
Gestational Trophoblastic Neoplasia	Gestational Trophoblastic Tumor
Gtn	Gestational Trophoblastic Disease
Gestational Trophoblastic Neoplasms	Hydatidiform Mole, Recurrent, 1
Hydatidiform Mole Benign	Trophoblastic Disease
Trophoblastic Disease Nos	Trophoblastic Disorder
Vesicular Mole Nos	Vesicular Mole
Hydatidiform Mole Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01693	C11orf80 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	C11orf80	MGD	MGI:2685806
Canis familiaris	C11orf80	VGNC	VGNC:59051
Rattus norvegicus	C11orf80	RGD	RGD:1563323
Macaca mulatta	C11orf80	VGNC	VGNC:100894
Felis catus	C11orf80	VGNC	VGNC:60593

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