TFPI2 - tissue factor pathway inhibitor 2 Gene

Homo sapiens

Also known as PP5; REF1; TFPI-2

Gene ID: 7980 | Gene type: protein coding

About TFPI2

Cytogenetic location: 7q21.3 Genomic coordinates (GRCh38): 7:93,885,396-93,890,753 (from NCBI)

This gene has 6 transcripts (splice variants), 206 orthologues and 13 paralogues. Biased expression in placenta (RPKM 566.0) and fat (RPKM 18.9).

Summary

This gene encodes a member of the Kunitz-type serine proteinase inhibitor family. The protein can inhibit a variety of serine proteases including factor VIIa/tissue factor, Factor Xa, plasmin, trypsin, chymotryspin and plasma Kallikrein. This gene has been identified as a tumor suppressor gene in several types of Cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

TFPI2 Products(3)

mRNA	Protein	Name
NM_001271003.2	NP_001257932.1	tissue factor pathway inhibitor 2 isoform 2 precursor
NM_001271004.2	NP_001257933.1	tissue factor pathway inhibitor 2 isoform 3 precursor
NM_006528.4	NP_006519.1	tissue factor pathway inhibitor 2 isoform 1 precursor

TFPI2 Protein Structure

Kunitz_BPTI

0
100
200
235 a.a.

Protein Preferred Names

Protein Names

tissue factor pathway inhibitor 2

placental protein 5

Recombinant TFPI2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71358	TFPI2 Protein, Human (HEK293, His)	P48307 (D23-K213)	≥95%
HY-P71358A	TFPI2 Protein, Human (HEK293, C-His)	P48307 (D23-K213)	≥95%

Related Diseases

Diseases

Alias

Fibrosarcoma

Neoplasms, Fibrous Tissue	Fibrocytic Tumor
Fibrosarcoma Of Soft Tissue	Fibrous Tissue Neoplasm

Choriocarcinoma

Chorioepithelioma

Hellp Syndrome

Hemolysis, Elevated Liver Enzymes, Lowered Platelets	Hemolysis, Elevated Liver Enzymes, Low Platelets In Pregnancy
Hemolysis-Elevated Liver Enzymes-Low Platelets Syndrome	Hellp - [Syndrome Of Haemolysis, Elevated Liver Enzymes And Low Platelet]
Haemolysis-Elevated Liver Enzymes-Low Platelet Count Syndrome

Ovarian Clear Cell Adenocarcinoma

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Brain Cancer

Adult Brain Tumor	Malignant Neoplasm Of Brain
Brain Neoplasms	Brain Neoplasm
Neoplasm Of Brain	Primary Malignant Neoplasm Of Brain
Brain Tumors	Adult Malignant Brain Neoplasm
Brain Neoplasm, Adult	Bt - Brain Tumour
Malignant Brain Tumour	Malignant Primary Brain Neoplasm
Malignant Primary Brain Tumor	Malignant Tumor Of Adult Brain
Malignant Tumor Of Brain	Primary Brain Neoplasm
Primary Brain Tumor	Tumor Of The Brain
Brain Tumor, Adult	Brain Tumor Primary
Malignant Primary Brain Tumors	Primary Brain Tumors
Cancer, Brain	Brain Tumor, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14428	TFPI2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TFPI2	VGNC	VGNC:47302
Rattus norvegicus	TFPI2	RGD	RGD:628629
Felis catus	TFPI2	VGNC	VGNC:66124
Macaca mulatta	TFPI2	VGNC	VGNC:78329
Mus musculus	TFPI2	MGD	MGI:108543
Bos taurus	TFPI2	VGNC	VGNC:35794
Others	TFPI2	NCBI

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