TFPI2 - tissue factor pathway inhibitor 2 Gene

Also Known as PP5; REF1; TFPI-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7980

About TFPI2

Cytogenetic location: 7q21.3 Genomic coordinates (GRCh38): 7:93,885,396-93,890,753 (from NCBI)

This gene has 6 transcripts (splice variants), 206 orthologues and 13 paralogues. Biased expression in placenta (RPKM 566.0) and fat (RPKM 18.9).

Summary

This gene encodes a member of the Kunitz-type serine proteinase inhibitor family. The protein can inhibit a variety of serine proteases including Factor VIIa/tissue factor, Factor Xa, plasmin, trypsin, chymotryspin and plasma Kallikrein. This gene has been identified as a tumor suppressor gene in several types of Cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

TFPI2 Products (3)

mRNA Protein Name
NM_001271003.2 NP_001257932.1 tissue factor pathway inhibitor 2 isoform 2 precursor
NM_001271004.2 NP_001257933.1 tissue factor pathway inhibitor 2 isoform 3 precursor
NM_006528.4 NP_006519.1 tissue factor pathway inhibitor 2 isoform 1 precursor

TFPI2 Protein Structure

Kunitz_BPTI

Kunitz_BPTI: Kunitz/Bovine pancreatic trypsin inhibitor domain (35 - 86)

Kunitz_BPTI

Kunitz_BPTI: Kunitz/Bovine pancreatic trypsin inhibitor domain (95 - 149)

Kunitz_BPTI

Kunitz_BPTI: Kunitz/Bovine pancreatic trypsin inhibitor domain (157 - 208)

  • 0
  • 100
  • 200
  • 235 a.a.
Protein Preferred Names Protein Names

tissue factor pathway inhibitor 2

  • placental protein 5

Recombinant TFPI2 Proteins

Cat. No. Product Name Accession Purity
HY-P71358 TFPI2 Protein, Human (HEK293, His) P48307 (D23-K213) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P71358A TFPI2 Protein, Human (HEK293, C-His) P48307 (D23-K213) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Fibrosarcoma

  • Neoplasms, Fibrous Tissue

  • Fibrocytic Tumor

  • Fibrosarcoma Of Soft Tissue

  • Fibrous Tissue Neoplasm
Choriocarcinoma

  • Chorioepithelioma
Hellp Syndrome

  • Hemolysis, Elevated Liver Enzymes, Lowered Platelets

  • Hemolysis, Elevated Liver Enzymes, Low Platelets In Pregnancy

  • Hemolysis-Elevated Liver Enzymes-Low Platelets Syndrome

  • Hellp - [Syndrome Of Haemolysis, Elevated Liver Enzymes And Low Platelet]

  • Haemolysis-Elevated Liver Enzymes-Low Platelet Count Syndrome
Ovarian Clear Cell Adenocarcinoma
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Brain Cancer

  • Adult Brain Tumor

  • Malignant Neoplasm Of Brain

  • Brain Neoplasms

  • Brain Neoplasm

  • Neoplasm Of Brain

  • Primary Malignant Neoplasm Of Brain

  • Brain Tumors

  • Adult Malignant Brain Neoplasm

  • Brain Neoplasm, Adult

  • Bt - Brain Tumour

  • Malignant Brain Tumour

  • Malignant Primary Brain Neoplasm

  • Malignant Primary Brain Tumor

  • Malignant Tumor Of Adult Brain

  • Malignant Tumor Of Brain

  • Primary Brain Neoplasm

  • Primary Brain Tumor

  • Tumor Of The Brain

  • Brain Tumor, Adult

  • Brain Tumor Primary

  • Malignant Primary Brain Tumors

  • Primary Brain Tumors

  • Cancer, Brain

  • Brain Tumor, Primary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14428 TFPI2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18411 Tfpi2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24892 Tfpi2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TFPI2 VGNC VGNC:47302
Rattus norvegicus TFPI2 RGD RGD:628629
Felis catus TFPI2 VGNC VGNC:66124
Macaca mulatta TFPI2 VGNC VGNC:78329
Mus musculus TFPI2 MGD MGI:108543
Bos taurus TFPI2 VGNC VGNC:35794
Others TFPI2 NCBI