PEAK1 - pseudopodium enriched atypical kinase 1 Gene

Also Known as SGK269

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79834

About PEAK1

Cytogenetic location: 15q24.3 Genomic coordinates (GRCh38): 15:77,100,654-77,420,914 (from NCBI)

This gene has 13 transcripts (splice variants), 217 orthologues and 3 paralogues. Ubiquitous expression in spleen (RPKM 15.5), lung (RPKM 8.0) and 23 other tissues.

Summary

This gene encodes a non-receptor tyrosine kinase that is a member of the new kinase family three (NFK3) family. In migrating cells, the encoded protein is associated with the actin Cytoskeleton and focal adhesions and promotes developing focal adhesion elongation. This protein may play a role in the regulation of cell migration, proliferation and Cancer metastasis. [provided by RefSeq, Mar 2014]

PEAK1 Products (5)

mRNA Protein Name
NM_001385026.1 NP_001371955.1 inactive tyrosine-protein kinase PEAK1 isoform a
NM_001385027.1 NP_001371956.1 inactive tyrosine-protein kinase PEAK1 isoform b
NM_001387085.1 NP_001374014.1 inactive tyrosine-protein kinase PEAK1 isoform a
NM_001387086.1 NP_001374015.1 inactive tyrosine-protein kinase PEAK1 isoform a
NM_024776.5 NP_079052.2 inactive tyrosine-protein kinase PEAK1 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
NOT enables ATP binding IDA
IDA: Inferred from direct assay
24107129 GOA
enables identical protein binding IDA
IDA: Inferred from direct assay
29212708 GOA
enables non-membrane spanning protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
20534451 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20534451 GOA
Biological Process GO Annotation Evidence References Source
involved in cell migration IDA
IDA: Inferred from direct assay
20534451 GOA
involved in cell migration IMP
IMP: Inferred from mutant phenotype
23105102 GOA
involved in focal adhesion assembly IMP
IMP: Inferred from mutant phenotype
23105102 GOA
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
20534451 GOA
involved in regulation of focal adhesion assembly IDA
IDA: Inferred from direct assay
23105102 GOA
involved in substrate adhesion-dependent cell spreading IDA
IDA: Inferred from direct assay
20534451 GOA
Cellular Component GO Annotation Evidence References Source
located in actin cytoskeleton IDA
IDA: Inferred from direct assay
20534451 GOA
located in focal adhesion IDA
IDA: Inferred from direct assay
20534451 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PEAK1 Protein Structure

Pkinase

Pkinase: Protein kinase domain (1456 - 1659)

  • 0
  • 300
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  • 1200
  • 1500
  • 1746 a.a.
Protein Preferred Names Protein Names

inactive tyrosine-protein kinase PEAK1

  • NKF3 kinase family member

PEAK1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PEAK1 Q9H792 BCAR1 Homo sapiens P56945
Anti Tag CoIP
20534451
Cross: Cross-species interaction Intra: Intraspecies interaction

PEAK1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P810261 SgK269 Antibody (YA9605) WB, IP, ELISA human

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-173117 RA306 Inhibitor 99.74% Unkown
HY-122792 Phenyramidol Hydrochloride / Unkown
HY-180464 Kv7.2/Kv7.3 modulator-3 Modulator / Unkown
HY-RS10310 PEAK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PEAK1 VGNC VGNC:64107
Rattus norvegicus PEAK1 RGD RGD:1312026
Canis familiaris PEAK1 VGNC VGNC:44407
Mus musculus PEAK1 MGD MGI:2442366
Macaca mulatta PEAK1 VGNC VGNC:84419
Bos taurus PEAK1 VGNC VGNC:32733
Others PEAK1 NCBI