Sost - sclerostin Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 80722

Summary

Predicted to enable BMP binding activity. Involved in ossification. Located in Golgi apparatus and extracellular space. Part of protein-containing complex. Human ortholog(s) of this gene implicated in SOST-related sclerosing bone dysplasia; autosomal dominant craniodiaphyseal dysplasia; sclerosteosis; and sclerosteosis 1. Orthologous to human SOST (sclerostin). [provided by Alliance of Genome Resources, Apr 2022]

Sost Products (1)

mRNA Protein Name
NM_030584.2 NP_085073.1 sclerostin precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15199066 RGD
Biological Process GO Annotation Evidence References Source
involved in ossification IEP
IEP: Inferred from expression pattern
15199066 RGD
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
17696759 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
15199066 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
15199066 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sclerostin

  • sclerosteosis

Recombinant Sost Proteins

Cat. No. Product Name Accession Purity
HY-P71623 SOST Protein, Rat (Myc, His) Q99P67 (F29-Y213) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-101149 YKL-05-093 Inhibitor / Unkown
HY-RS13578 SOST Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16993 Sost Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23436 Sost Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992113 Evabosmig Activator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sost NCBI NCBI:50964