DCSTAMP - dendrocyte expressed seven transmembrane protein Gene

Also Known as FIND; TM7SF4; hDC-STAMP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 81501

About DCSTAMP

Cytogenetic location: 8q22.3 Genomic coordinates (GRCh38): 8:104,339,796-104,356,689 (from NCBI)

This gene has 8 transcripts (splice variants), 206 orthologues and 3 paralogues. Biased expression in lung (RPKM 1.3), liver (RPKM 0.2) and 4 other tissues.

Summary

This gene encodes a seven-pass transmembrane protein that is primarily expressed in dendritic cells. The encoded protein is involved in a range of immunological functions carried out by dendritic cells. This protein plays a role in osteoclastogenesis and myeloid differentiation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]

DCSTAMP Products (2)

mRNA	Protein	Name
NM_001257317.1	NP_001244246.1	dendritic cell-specific transmembrane protein isoform 2
NM_030788.4	NP_110415.1	dendritic cell-specific transmembrane protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20546900	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to interleukin-4	IDA IDA: Inferred from direct assay	15601667	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	11169400	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	15601667	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DCSTAMP Protein Structure

DC_STAMP

0
100
200
300
400
470 a.a.

Protein Preferred Names	Protein Names
dendritic cell-specific transmembrane protein	DC-specific transmembrane protein

DCSTAMP Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DCSTAMP	Q9H295	CREB3	Homo sapiens	O43889-2	Y2H	20546900
Intra	DCSTAMP	Q9H295	CREB3	Homo sapiens	O43889-2	Confocal	20546900

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Mammary Paget'S Disease	Paget'S Disease Mammary Paget Disease Paget'S Disease Of The Breast Paget Disease Of The Breast Paget'S Disease Of The Nipple Paget'S Disease, Mammary Paget Cell Neoplasm Paget Disease Of The Nipple Pagets Disease Mammary Osteitis Deformans
Paget'S Disease Of Bone	Osteitis Deformans Paget Disease Of Bone Osseous Paget'S Disease Paget Disease Of Bone, Familial Bone Paget Disease Familial Paget'S Disease Of Bone Paget'S Bone Disease Familial Paget Disease Of Bone Paget Disease, Bone Pdb Pagets Bone Disease
Bone Remodeling Disease
Osteopetrosis	Marble Bone Disease Albers-Schonberg Disease Osteopetroses Marble Bones Osteopetrosis And Related Disorders Congenital Osteopetrosis Marble Bone Albers-Schoenberg Disease Albers-Schonberg Osteopetrosis Osteosclerosis Fragilis Ivory Bones
Bone Resorption Disease	Bone Resorption
Ischemic Bone Disease
Breast Adenocarcinoma	Mammary Adenocarcinoma Adenocarcinoma Of Breast

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-117200	Necrostatin-7	Inhibitor	99.64%	Unkown
HY-180801	E8431		97.34%	Unkown
HY-RS03590	DCSTAMP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	DCSTAMP	VGNC	VGNC:81645
Macaca mulatta	DCSTAMP	VGNC	VGNC:71659
Rattus norvegicus	DCSTAMP	RGD	RGD:1310435
Bos taurus	DCSTAMP	VGNC	VGNC:27925
Canis familiaris	DCSTAMP	VGNC	VGNC:49724
Mus musculus	DCSTAMP	MGD	MGI:1923016
Others	DCSTAMP	NCBI