Jup - junction plakoglobin Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 81679

Summary

Enables protein kinase binding activity. Predicted to be involved in several processes, including cellular response to indole-3-methanol; regulation of heart contraction; and regulation of transcription, DNA-templated. Predicted to act upstream of or within cell-cell adhesion; desmosome assembly; and skin development. Located in several cellular components, including apicolateral plasma membrane; fascia adherens; and lateral plasma membrane. Colocalizes with actin Cytoskeleton. Human ortholog(s) of this gene implicated in cardiomyopathy (multiple); palmoplantar keratosis (multiple); renal cell carcinoma; and reproductive organ Cancer (multiple). Orthologous to human JUP (junction plakoglobin). [provided by Alliance of Genome Resources, Apr 2022]

Jup Products (1)

mRNA Protein Name
NM_031047.2 NP_112309.2 junction plakoglobin

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21062920 RGD
enables protein kinase binding IPI
IPI: Inferred from physical interaction
12700184 RGD
enables protein tyrosine kinase binding IPI
IPI: Inferred from physical interaction
12700184 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
8834786 RGD
Cellular Component GO Annotation Evidence References Source
located in actin cytoskeleton IDA
IDA: Inferred from direct assay
12478657 RGD
located in adherens junction IDA
IDA: Inferred from direct assay
8834786 RGD
located in apicolateral plasma membrane IDA
IDA: Inferred from direct assay
10335358 RGD
located in cell-cell junction IDA
IDA: Inferred from direct assay
12478657 RGD
located in cytoplasmic side of plasma membrane IDA
IDA: Inferred from direct assay
12478657 RGD
located in desmosome IDA
IDA: Inferred from direct assay
16406610 RGD
located in fascia adherens IDA
IDA: Inferred from direct assay
16406610 RGD
located in lateral plasma membrane IDA
IDA: Inferred from direct assay
10335358 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

junction plakoglobin

  • gamma-catenin (plakoglobin)

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07061 JUP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18118 Jup Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24592 Jup Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Jup NCBI NCBI:3728