Lifr - LIF receptor subunit alpha Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 81680

Summary

Enables cytokine binding activity and Leukemia Inhibitory Factor receptor activity. Involved in several processes, including animal organ regeneration; negative regulation of muscle cell apoptotic process; and neuron projection morphogenesis. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in osteochondrodysplasia. Orthologous to human LIFR (LIF receptor subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]

Lifr Products (2)

mRNA Protein Name
NM_031048.1 NP_112310.1 leukemia inhibitory factor receptor precursor
NM_031048.1 NP_112310.1 leukemia inhibitory factor receptor precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables cytokine binding IMP
IMP: Inferred from mutant phenotype
14638908 RGD
enables leukemia inhibitory factor receptor activity IMP
IMP: Inferred from mutant phenotype
14638908 RGD
Biological Process GO Annotation Evidence References Source
involved in animal organ regeneration IMP
IMP: Inferred from mutant phenotype
14638908 RGD
involved in negative regulation of muscle cell apoptotic process IMP
IMP: Inferred from mutant phenotype
15927854 RGD
involved in neuron projection morphogenesis IDA
IDA: Inferred from direct assay
12871977 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
16698589 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

leukemia inhibitory factor receptor

  • LIF receptor alpha

  • LIF-R

  • leukemia inhibitor factor receptor alpha-chain

  • leukemia inhibitory factor receptor alpha

Recombinant Lifr Proteins

Cat. No. Product Name Accession Purity
HY-P75907 LIFR Protein, Rat (HEK293, His) G3V7K2 (L44-S829) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-120142 EC359 Inducer 99.77% Unkown
HY-169192 BAR-2227 Agonist / Unkown
HY-178477 LIFR/GPBAR1 modulator 1 / Unkown
HY-RS07641 LIFR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17192 Lifr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23643 Lifr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lifr NCBI NCBI:3977