Rnpep - arginyl aminopeptidase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 81761

About Rnpep

Primary_assembly 13: 46,699,463-46,717,998 reverse strand.mRatBN7.2:CM026986.1

This gene has 2 transcripts (splice variants), 156 orthologues, 10 paralogues and is associated with 6 phenotypes. Biased expression in Kidney (RPKM 14.6), Testes (RPKM 139.5) and 9 other tissues.

Summary

Enables metalloaminopeptidase activity; peptide binding activity; and transition metal ion binding activity. Involved in several processes, including aging; negative regulation of blood pressure; and retina development in camera-type eye. Located in several cellular components, including Golgi apparatus; external side of plasma membrane; and secretory granule. Used to study hypertension. Biomarker of hypertension. Orthologous to human RNPEP (arginyl Aminopeptidase). [provided by Alliance of Genome Resources, Apr 2022]

Rnpep Products (1)

mRNA Protein Name
NM_031097.2 NP_112359.2 aminopeptidase B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables aminopeptidase activity IDA
IDA: Inferred from direct assay
8940051 RGD
enables cobalt ion binding IDA
IDA: Inferred from direct assay
17142967 RGD
enables copper ion binding IDA
IDA: Inferred from direct assay
17142967 RGD
enables metalloaminopeptidase activity IDA
IDA: Inferred from direct assay
17142967 RGD
enables peptide binding IDA
IDA: Inferred from direct assay
16537183 RGD
enables zinc ion binding IDA
IDA: Inferred from direct assay
17142967 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
3001599 RGD
involved in protein processing IDA
IDA: Inferred from direct assay
16537183 RGD
involved in retina development in camera-type eye IEP
IEP: Inferred from expression pattern
15500823 RGD
Cellular Component GO Annotation Evidence References Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
9405297 RGD
located in extracellular region IDA
IDA: Inferred from direct assay
9405297 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
16619500 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
9405297 RGD
located in secretory granule IDA
IDA: Inferred from direct assay
15539558 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Rnpep Protein Structure

M1_LTA4H

M1_LTA4H: cd09599 (23 - 483)

Leuk-A4-hydro_C

Leuk-A4-hydro_C: pfam09127 (529 - 644)

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  • 650 a.a.
Protein Preferred Names Protein Names

aminopeptidase B

  • AP-B

  • arginine aminopeptidase

  • cytosol aminopeptidase IV

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12104 RNPEP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12105 Rnpep Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12106 Rnpep Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rnpep NCBI NCBI:6051