QTRT1 - queuine tRNA-ribosyltransferase catalytic subunit 1 Gene

Also Known as TGT; TGUT; FP3235

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 81890

About QTRT1

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:10,701,439-10,713,365 (from NCBI)

This gene has 12 transcripts (splice variants), 186 orthologues and 1 paralogue. Ubiquitous expression in ovary (RPKM 18.9), thyroid (RPKM 17.4) and 25 other tissues.

Summary

This gene encodes the catalytic subunit of tRNA-guanine transglycosylase. tRNA-guanine transglycosylase is a heterodimeric enzyme complex that plays a critical role in tRNA modification by synthesizing the 7-deazaguanosine queuosine, which is found in tRNAs that code for asparagine, aspartic acid, histidine and tyrosine. A pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, Feb 2012]

QTRT1 Products (1)

mRNA Protein Name
NM_031209.3 NP_112486.1 queuine tRNA-ribosyltransferase catalytic subunit 1
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20354154 GOA
enables protein heterodimerization activity IDA
IDA: Inferred from direct assay
20354154 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
20354154 GOA
enables tRNA-guanosine(34) queuine transglycosylase activity IDA
IDA: Inferred from direct assay
20354154 GOA
Biological Process GO Annotation Evidence References Source
involved in tRNA-guanine transglycosylation IDA
IDA: Inferred from direct assay
20354154 GOA
Cellular Component GO Annotation Evidence References Source
part of tRNA-guanine transglycosylase complex IPI
IPI: Inferred from physical interaction
20354154 GOA
part of transferase complex IPI
IPI: Inferred from physical interaction
20354154 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

QTRT1 Protein Structure

TGT

TGT: Queuine tRNA-ribosyltransferase (141 - 377)

  • 0
  • 100
  • 200
  • 300
  • 403 a.a.
Protein Preferred Names Protein Names

queuine tRNA-ribosyltransferase catalytic subunit 1

  • TGT, 43-KD subunit

Related Diseases

Diseases Alias
Dyschromatosis Universalis Hereditaria
  • Duh

Atrophic Rhinitis
  • Rhinitis, Atrophic

  • Ozena

  • Rhinitis Sicca

  • Dry Rhinitis

  • Ozaena

Noonan Syndrome 1
  • Noonan Syndrome

  • NS1

  • Male Turner Syndrome

  • Female Pseudo-Turner Syndrome

  • Turner Phenotype With Normal Karyotype

  • Noonan Syndrome With Pigmented Villonodular Synovitis

  • Turner'S Phenotype, Karyotype Normal

  • Familial Turner Syndrome

  • Noonan'S Syndrome

  • Noonan-Ehmke Syndrome

  • Ns

  • Pseudo-Ullrich-Turner Syndrome

  • Turner Syndrome In Female With X Chromosome

  • Turner-Like Syndrome

  • Ullrich-Noonan Syndrome

  • Noonan-Like/Multiple Giant Cell Lesion Syndrome

  • Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions

  • Pterygium Colli Syndrome

  • Noonan Syndrome, Type 1

  • Turner Syndrome, Male

Benign Epilepsy With Centrotemporal Spikes
  • Rolandic Epilepsy

  • Benign Rolandic Epilepsy

  • Epilepsy, Rolandic

  • Bcects

  • Benign Childhood Epilepsy With Centrotemporal Spike

  • Sylvan Seizures

  • Becrs

  • Bects

  • Bre

  • Benign Epilepsy Of Childhood With Centrotemporal Spikes

  • Benign Familial Epilepsy Of Childhood With Rolandic Spikes

  • Centrotemporal Epilepsy

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus QTRT1 RGD RGD:620996
Bos taurus QTRT1 VGNC VGNC:33607
Canis familiaris QTRT1 VGNC VGNC:45240
Mus musculus QTRT1 MGD MGI:1931441
Felis catus QTRT1 VGNC VGNC:64463
Others QTRT1 NCBI