QTRT1 - queuine tRNA-ribosyltransferase catalytic subunit 1 Gene
Also Known as TGT; TGUT; FP3235
Species: Homo sapiens
About QTRT1
This gene has 12 transcripts (splice variants), 186 orthologues and 1 paralogue. Ubiquitous expression in ovary (RPKM 18.9), thyroid (RPKM 17.4) and 25 other tissues.
Summary
This gene encodes the catalytic subunit of tRNA-guanine transglycosylase. tRNA-guanine transglycosylase is a heterodimeric enzyme complex that plays a critical role in tRNA modification by synthesizing the 7-deazaguanosine queuosine, which is found in tRNAs that code for asparagine, aspartic acid, histidine and tyrosine. A pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, Feb 2012]
QTRT1 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_031209.3 | NP_112486.1 | queuine tRNA-ribosyltransferase catalytic subunit 1 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
20354154 | GOA |
| enables protein heterodimerization activity |
IDA
IDA: Inferred from direct assay
|
20354154 | GOA |
| enables protein homodimerization activity |
IDA
IDA: Inferred from direct assay
|
20354154 | GOA |
| enables tRNA-guanosine(34) queuine transglycosylase activity |
IDA
IDA: Inferred from direct assay
|
20354154 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in tRNA-guanine transglycosylation |
IDA
IDA: Inferred from direct assay
|
20354154 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| part of tRNA-guanine transglycosylase complex |
IPI
IPI: Inferred from physical interaction
|
20354154 | GOA |
| part of transferase complex |
IPI
IPI: Inferred from physical interaction
|
20354154 | GOA |
QTRT1 Protein Structure
TGT: Queuine tRNA-ribosyltransferase (141 - 377)
- 0
- 100
- 200
- 300
- 403 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
queuine tRNA-ribosyltransferase catalytic subunit 1 |
|
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Dyschromatosis Universalis Hereditaria |
|
|
| Atrophic Rhinitis |
|
|
| Noonan Syndrome 1 |
|
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| Benign Epilepsy With Centrotemporal Spikes |
|
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Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | QTRT1 | RGD | RGD:620996 |
| Bos taurus | QTRT1 | VGNC | VGNC:33607 |
| Canis familiaris | QTRT1 | VGNC | VGNC:45240 |
| Mus musculus | QTRT1 | MGD | MGI:1931441 |
| Felis catus | QTRT1 | VGNC | VGNC:64463 |
| Others | QTRT1 | NCBI |