KDM5D - lysine demethylase 5D Gene

Also Known as HY; HYA; SMCY; JARID1D

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8284

About KDM5D

Cytogenetic location: Yq11.223 Genomic coordinates (GRCh38): Y:19,703,865-19,744,726 (from NCBI)

This gene has 10 transcripts (splice variants), 110 orthologues, 10 paralogues and is associated with 1 phenotype. Broad expression in small intestine (RPKM 5.6), prostate (RPKM 3.5) and 20 other tissues.

Summary

This gene encodes a protein containing zinc finger domains. A short peptide derived from this protein is a minor histocompatibility antigen which can lead to graft rejection of male donor cells in a female recipient. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

KDM5D Products (3)

mRNA Protein Name
NM_001146705.2 NP_001140177.1 lysine-specific demethylase 5D isoform 1
NM_001146706.2 NP_001140178.1 lysine-specific demethylase 5D isoform 3
NM_004653.5 NP_004644.2 lysine-specific demethylase 5D isoform 2

KDM5D Protein Structure

JmjN

JmjN: jmjN domain (15 - 48)

ARID

ARID: ARID/BRIGHT DNA binding domain (77 - 165)

PHD

PHD: PHD-finger (316 - 362)

JmjC

JmjC: JmjC domain, hydroxylase (491 - 607)

zf-C5HC2

zf-C5HC2: C5HC2 zinc finger (697 - 750)

PLU-1

PLU-1: PLU-1-like protein (761 - 1087)

PHD

PHD: PHD-finger (1174 - 1236)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1539 a.a.
Protein Preferred Names Protein Names

lysine-specific demethylase 5D

  • H-Y

KDM5D Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
KDM5D Q9BY66 AR Homo sapiens P10275
Anti Bait CoIP
27185910
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Spermatogenic Failure, Y-Linked, 2

  • SPGFY2

  • Spermatogenic Failure, Nonobstructive, Y-Linked

  • Y-Linked Spermatogenic Failure 2

  • Azoospermia, Nonobstructive, Y-Linked

  • Oligozoospermia, Nonobstructive, Y-Linked

  • Oligospermia, Nonobstructive, Y-Linked

  • Spermatogenic Arrest, Y-Linked

  • Nonobstructive Y-Linked Spermatogenic Failure

  • Spermatogenic Failure Y-Linked 2

  • Azoospermia Non-Obstructive Y-Linked

  • Non-Obstructive Azoospermia And Infertility

  • Oligospermia Non-Obstructive Y-Linked

  • Oligozoospermia Non-Obstructive Y-Linked

  • Spermatogenic Arrest Y-Linked

  • Spermatogenic Failure Nonobstructive Y-Linked
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-102047B KDOAM-25 citrate Inhibitor 98.56% Unkown
HY-102047 KDOAM-25 Inhibitor / Unkown
HY-RS07221 KDM5D Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-102047A KDOAM-25 trihydrochloride Inhibitor / Unkown
HY-RS17171 Kdm5d Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23621 Kdm5d Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus KDM5D MGD MGI:99780
Macaca mulatta KDM5D VGNC VGNC:101430
Rattus norvegicus KDM5D RGD RGD:2314436
Others KDM5D NCBI