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FZD1 - frizzled class receptor 1 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8321

About FZD1

Cytogenetic location: 7q21.13 Genomic coordinates (GRCh38): 7:91,264,433-91,271,326 (from NCBI)

This gene has 1 transcript (splice variant), 193 orthologues and 15 paralogues.

Summary

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues. [provided by RefSeq, Jul 2008]

FZD1 Products (1)

mRNA	Protein	Name
NM_003505.2	NP_003496.1	frizzled-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables PDZ domain binding	IPI IPI: Inferred from physical interaction	19388021	GOA
enables Wnt receptor activity	IDA IDA: Inferred from direct assay	10557084	GOA
enables Wnt-protein binding	IPI IPI: Inferred from physical interaction	10557084	GOA
enables frizzled binding	IPI IPI: Inferred from physical interaction	19188438	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19277043	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	14739301	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in autocrine signaling	IDA IDA: Inferred from direct assay	10557084	GOA
involved in canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	10557084	GOA
involved in canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	11433302	GOA
involved in canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	20039315	GOA
involved in cell-cell signaling	IDA IDA: Inferred from direct assay	10557084	GOA
involved in positive regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	10557084	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	18929644	GOA
involved in positive regulation of osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	20039315	GOA
involved in regulation of mesenchymal stem cell differentiation	IMP IMP: Inferred from mutant phenotype	20039315	GOA
involved in response to xenobiotic stimulus	IMP IMP: Inferred from mutant phenotype	19421142	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	19643732	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FZD1 Protein Structure

Frizzled

0
100
200
300
400
500
600
647 a.a.

Protein Preferred Names	Protein Names
frizzled-1	Wnt receptor

Related Diseases

Diseases	Alias
Omodysplasia	Omodysplasia Type 1 Omodysplasia 2
Fallopian Tube Serous Adenocarcinoma
Exudative Vitreoretinopathy	Familial Exudative Vitreoretinopathy Fevr Criswick-Schepens Syndrome Exudative Vitreoretinopathy, Familial Vitreoretinopathy, Exudative ) Exudative Vitreoretinopathy 1
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Norrie Disease	Atrophia Bulborum Hereditaria Episkopi Blindness Pseudoglioma ND Norrie-Warburg Disease Anderson-Warburg Syndrome Fetal Iritis Syndrome Norrie Syndrome Norrie-Warburg Syndrome Ndp Congenital Progressive Oculo-Acoustico-Cerebral Degeneration Norrie'S Disease Oligophrenia Microphthalmus Pseudoglioma Congenita Whitnall-Norman Syndrome
Robinow Syndrome	Acral Dysostosis With Facial And Genital Abnormalities Fetal Face Syndrome Robinow Dwarfism Mesomelic Dwarfism-Small Genitalia Syndrome Robinow-Silverman-Smith Syndrome Costovertebral Segmentation Defect With Mesomelia Covesdem Syndrome Robinow'S Syndrome Robinow-Silverman Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive MoleculesInhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P9974	Vantictumab	Inhibitor	99.40%	Phase 1

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05176	FZD1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18358	Fzd1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24837	Fzd1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	FZD1	MGD	MGI:1196625
Felis catus	FZD1	VGNC	VGNC:62402
Rattus norvegicus	FZD1	RGD	RGD:61916
Canis familiaris	FZD1	VGNC	VGNC:41028
Bos taurus	FZD1	VGNC	VGNC:29165
Others	FZD1	NCBI