ELOVL3 - ELOVL fatty acid elongase 3 Gene

Also Known as CIG30; CIG-30

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 83401

About ELOVL3

Cytogenetic location: 10q24.32 Genomic coordinates (GRCh38): 10:102,224,767-102,229,589 (from NCBI)

This gene has 1 transcript (splice variant), 264 orthologues and 6 paralogues. Biased expression in fat (RPKM 1.4), skin (RPKM 0.7) and 8 other tissues.

Summary

This gene encodes a protein that belongs to the GNS1/SUR4 family. Members of this family play a role in elongation of long chain fatty acids to provide precursors for synthesis of sphingolipids and ceramides. [provided by RefSeq, Jul 2013]

ELOVL3 Products (1)

mRNA Protein Name
NM_152310.3 NP_689523.1 elongation of very long chain fatty acids protein 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables fatty acid elongase activity EXP
EXP: Inferred from Experiment
10970790 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20937905 GOA
Biological Process GO Annotation Evidence References Source
involved in fatty acid elongation, monounsaturated fatty acid IDA
IDA: Inferred from direct assay
20937905 GOA
involved in fatty acid elongation, polyunsaturated fatty acid IDA
IDA: Inferred from direct assay
20937905 GOA
involved in fatty acid elongation, saturated fatty acid IDA
IDA: Inferred from direct assay
20937905 GOA
involved in very long-chain fatty acid biosynthetic process IDA
IDA: Inferred from direct assay
20937905 GOA
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
20937905 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ELOVL3 Protein Structure

ELO

ELO: GNS1/SUR4 family (32 - 265)

  • 0
  • 100
  • 200
  • 270 a.a.
Protein Preferred Names Protein Names

elongation of very long chain fatty acids protein 3

  • 3-keto acyl-CoA synthase ELOVL3

Related Diseases

Diseases Alias
Spinocerebellar Ataxia 38

  • Spinocerebellar Ataxia Type 38

  • SCA38

  • Ataxia, Spinocerebellar, Type 38
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-152947 ELOVL6-IN-4 98.94% Unkown
HY-RS04323 ELOVL3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20548 Elovl3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27057 Elovl3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ELOVL3 VGNC VGNC:72064
Mus musculus ELOVL3 MGD MGI:1195976
Canis familiaris ELOVL3 VGNC VGNC:40321
Rattus norvegicus ELOVL3 RGD RGD:1307263
Bos taurus ELOVL3 VGNC VGNC:28449
Others ELOVL3 NCBI