Nme2 - NME/NM23 nucleoside diphosphate kinase 2 Gene

Also Known as NDKB; nm23-2; p18-12d

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 83782

Summary

Enables several functions, including identical protein binding activity; intermediate filament binding activity; and kinase activity. Involved in several processes, including cellular response to glucose stimulus; nucleotide metabolic process; and response to growth hormone. Located in mitochondrial membrane and perinuclear region of cytoplasm. Colocalizes with intermediate filament. Human ortholog(s) of this gene implicated in teratoma. Orthologous to several human genes including NME1-NME2 (NME1-NME2 readthrough). [provided by Alliance of Genome Resources, Apr 2022]

Nme2 Products (1)

mRNA	Protein	Name
NM_031833.2	NP_114021.2	nucleoside diphosphate kinase B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	17572440	RGD
enables fatty acid binding	IPI IPI: Inferred from physical interaction	18084788	RGD
enables heterocyclic compound binding	IPI IPI: Inferred from physical interaction	1316151	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	1316152	RGD
enables intermediate filament binding	IPI IPI: Inferred from physical interaction	11082283	RGD
enables nucleoside diphosphate kinase activity	IDA IDA: Inferred from direct assay	8142475	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	17532299	RGD
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	9000516	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in CTP biosynthetic process	IDA IDA: Inferred from direct assay	1316151	RGD
involved in GTP biosynthetic process	IDA IDA: Inferred from direct assay	1316151	RGD
involved in UTP biosynthetic process	IDA IDA: Inferred from direct assay	1316151	RGD
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	17363702	RGD
involved in cellular response to fatty acid	IEP IEP: Inferred from expression pattern	19367376	RGD
involved in cellular response to glucose stimulus	IEP IEP: Inferred from expression pattern	19367376	RGD
involved in cellular response to oxidative stress	IEP IEP: Inferred from expression pattern	18442093	RGD
involved in negative regulation of myeloid leukocyte differentiation	IDA IDA: Inferred from direct assay	7737424	RGD
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	10069391	RGD
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	9000516	RGD
involved in response to growth hormone	IEP IEP: Inferred from expression pattern	16127721	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in intermediate filament	IDA IDA: Inferred from direct assay	11082283	RGD
located in mitochondrial membrane	IDA IDA: Inferred from direct assay	11831846	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	11082283	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
nucleoside diphosphate kinase B	NDK B NDP kinase B NDP kinase alpha P18 expressed in non-metastatic cells 2 histidine protein kinase NDKB non-metastatic cells 2, protein (NM23B) expressed in

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N6747	Stauprimide	Inhibitor	99.45%	Unkown
HY-W591768	(E)-4-(4-(Dimethylamino)styryl)-1-methylpyridin-1-ium iodide		99.66%	Unkown
HY-RS09373	NME2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-170436	NFh-NMe-2	Inducer	/	Unkown
HY-RS09372	NME1-NME2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19360	Nme2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25852	Nme2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nme2	NCBI	NCBI:4831