Fdps - farnesyl diphosphate synthase Gene

Also Known as FPS; Ac2-125

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 83791

Summary

Enables geranyltranstransferase activity. Involved in several processes, including farnesyl diphosphate biosynthetic process; positive regulation of cell growth involved in cardiac muscle cell development; and positive regulation of Cholesterol biosynthetic process. Located in mitochondrial matrix and peroxisome. Human ortholog(s) of this gene implicated in porokeratosis. Orthologous to human FDPS (farnesyl diphosphate synthase). [provided by Alliance of Genome Resources, Apr 2022]

Fdps Products (1)

mRNA	Protein	Name
NM_031840.1	NP_114028.1	farnesyl pyrophosphate synthase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables geranyltranstransferase activity	IDA IDA: Inferred from direct assay	8188698	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to fatty acid	IEP IEP: Inferred from expression pattern	15473864	RGD
involved in farnesyl diphosphate biosynthetic process	IDA IDA: Inferred from direct assay	8188698	RGD
involved in male gonad development	IEP IEP: Inferred from expression pattern	1917693	RGD
involved in positive regulation of cell growth involved in cardiac muscle cell development	IMP IMP: Inferred from mutant phenotype	19716825	RGD
involved in positive regulation of cholesterol biosynthetic process	IMP IMP: Inferred from mutant phenotype	18637708	RGD
involved in response to cholesterol	IEP IEP: Inferred from expression pattern	2909544	RGD
involved in response to peptide hormone	IEP IEP: Inferred from expression pattern	1917693	RGD
involved in response to testosterone	IEP IEP: Inferred from expression pattern	12890564	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	15084352	RGD
involved in spermatogenesis	IEP IEP: Inferred from expression pattern	2043737	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in mitochondrial matrix	IDA IDA: Inferred from direct assay	8119922	RGD
located in peroxisome	IDA IDA: Inferred from direct assay	8188698	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
farnesyl pyrophosphate synthase	(2E,6E)-farnesyl diphosphate synthase CR 39 FPP synthase FPP synthetase cholesterol-regulated 39 kDa protein dimethylallyltranstransferase farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranst

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-106950A	Fosfructose trisodium		98.0%	Unkown
HY-148077	Phosphoglycolohydroxamic acid	Inhibitor	98.0%	Unkown
HY-B0631S	Alendronic acid-d6		98.0%	Unkown
HY-RS04853	FDPS Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17189	Fdps Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23640	Fdps Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fdps	NCBI	NCBI:2224