Kalrn - kalirin, RhoGEF kinase Gene

Also Known as Duo; Hapip; Kalirin

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 84009

Summary

Enables enzyme binding activity. Involved in several processes, including NMDA selective glutamate receptor signaling pathway; modification of postsynaptic actin cytoskeleton; and neurotransmitter receptor localization to postsynaptic specialization membrane. Located in neuron projection; neuronal cell body; and perinuclear region of cytoplasm. Is active in glutamatergic synapse; postsynaptic density; and presynapse. Orthologous to human KALRN (kalirin RhoGEF kinase). [provided by Alliance of Genome Resources, Apr 2022]

Kalrn Products (1)

mRNA	Protein	Name
NM_032062.2	NP_114451.2	kalirin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	8910496	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	9285789	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in axonogenesis	IDA IDA: Inferred from direct assay	12177196	RGD
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	12177196	RGD
involved in nervous system development	IDA IDA: Inferred from direct assay	12177196	RGD
involved in regulation of dendrite development	IDA IDA: Inferred from direct assay	14627644	RGD
involved in regulation of modification of postsynaptic actin cytoskeleton	IDA IDA: Inferred from direct assay	18031682	RGD
involved in regulation of modification of postsynaptic actin cytoskeleton	IMP IMP: Inferred from mutant phenotype	18031682	RGD
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IDA IDA: Inferred from direct assay	18031682	RGD
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IMP IMP: Inferred from mutant phenotype	18031682	RGD

Cellular Component GO Annotation	Evidence	References	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	18031682	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	18031682	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	10777487	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	10777487	RGD
is active in postsynaptic density	IDA IDA: Inferred from direct assay	18031682	RGD
is active in postsynaptic density	IMP IMP: Inferred from mutant phenotype	18031682	RGD
is active in presynapse	EXP EXP: Inferred from Experiment	23622064	RGD
is active in presynapse	IDA IDA: Inferred from direct assay	23622064	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
kalirin	P-CIP10 PAM COOH-terminal interactor protein 10 cyclin B1 huntingtin-associated protein interacting protein (duo) huntingtin-associated protein-interacting protein protein Duo serine/threonine kinase with Dbl- and pleckstrin homology domain serine/

Kalrn Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Kalrn	P97924	Hap1	Rattus norvegicus	P54256	Pull Down	9285789
Intra	Kalrn	P97924	Hap1	Rattus norvegicus	P54256	Y2H	9285789

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07062	KALRN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kalrn	NCBI	NCBI:8997