Hcn1 - hyperpolarization-activated cyclic nucleotide-gated potassium channel 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 84390

Summary

Enables identical protein binding activity; phosphatidylinositol phosphate binding activity; and protein C-terminus binding activity. Involved in several processes, including cellular response to interferon-beta; maternal behavior; and response to L-glutamate. Located in several cellular components, including basolateral plasma membrane; dendrite; and neuronal cell body. Used to study anxiety disorder and mood disorder. Biomarker of complex cortical dysplasia with Other brain malformations; epilepsy (multiple); and meningitis. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 24 and generalized epilepsy with febrile seizures plus 10. Orthologous to human HCN1 (hyperpolarization activated cyclic nucleotide gated Potassium Channel 1). [provided by Alliance of Genome Resources, Apr 2022]

Hcn1 Products (1)

mRNA Protein Name
NM_053375.2 NP_445827.2 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IDA
IDA: Inferred from direct assay
19008224 RGD
enables phosphatidylinositol-3,4,5-trisphosphate binding IDA
IDA: Inferred from direct assay
22948144 RGD
enables phosphatidylinositol-4,5-bisphosphate binding IDA
IDA: Inferred from direct assay
22948144 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
17988239 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to interferon-beta IEP
IEP: Inferred from expression pattern
23042740 RGD
involved in maternal behavior IEP
IEP: Inferred from expression pattern
16820024 RGD
involved in negative regulation of action potential IMP
IMP: Inferred from mutant phenotype
22884333 RGD
involved in positive regulation of cation channel activity IDA
IDA: Inferred from direct assay
20806410 RGD
involved in positive regulation of membrane hyperpolarization IMP
IMP: Inferred from mutant phenotype
30408474 RGD
involved in regulation of membrane depolarization IDA
IDA: Inferred from direct assay
20806410 RGD
involved in regulation of membrane hyperpolarization IMP
IMP: Inferred from mutant phenotype
22884333 RGD
involved in response to L-glutamate IEP
IEP: Inferred from expression pattern
20215108 RGD
involved in response to calcium ion IDA
IDA: Inferred from direct assay
19008224 RGD
Cellular Component GO Annotation Evidence References Source
located in apical dendrite IDA
IDA: Inferred from direct assay
19458150 RGD
located in axon IDA
IDA: Inferred from direct assay
17439493 RGD
located in axon terminus IDA
IDA: Inferred from direct assay
17460082 RGD
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
11675786 RGD
located in cell surface IDA
IDA: Inferred from direct assay
20215108 RGD
located in dendrite IDA
IDA: Inferred from direct assay
24451387 RGD
located in dendrite membrane IDA
IDA: Inferred from direct assay
23324324 RGD
located in dendritic shaft IDA
IDA: Inferred from direct assay
17439493 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
24451387 RGD
located in somatodendritic compartment IDA
IDA: Inferred from direct assay
23324324 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-18940 Cilobradine / Phase 2
HY-W040555 Norquetiapine dihydrochloride 99.91% Phase 1

Pre-clinical Phase

Bioactive Molecules (17)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-160505 RO-275 Inhibitor 99.95% Unkown
HY-13422A Zatebradine Antagonist 99.27% Unkown
HY-13422 Zatebradine hydrochloride Antagonist 99.87% Unkown
HY-W052508 Norquetiapine 99.95% Unkown
HY-163455 pan-HCN-IN-1 Inhibitor 99.84% Unkown
HY-108574 CP 339818 hydrochloride Inhibitor 99.61% Unkown
HY-W052508S Norquetiapine-d8 / Unkown
HY-114540 CP-339818 Inhibitor / Unkown
HY-182459 Org 34167 (freebase) Modulator / Unkown
HY-186057 HCN2-IN-5 Inhibitor / Unkown
HY-186059 HCN2 modulator-4 Inhibitor / Unkown
HY-186059A HCN2 modulator-5 Inhibitor / Unkown
HY-186060 HCN2 modulator-6 Inhibitor / Unkown
HY-186061A HCN2 modulator-8 Inhibitor / Unkown
HY-RS06046 HCN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22198 Hcn1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28720 Hcn1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hcn1 NCBI NCBI:348980